Abstract
The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2555-2562 |
| Number of pages | 8 |
| Journal | Journal of Neuroscience |
| Volume | 12 |
| Issue number | 7 |
| State | Published - 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)