Chromosomal localization of human glutamate receptor genes

J. O. McNamara; J. H. Eubanks; John Douglas Mcpherson; J. J. Wasmuth; G. A. Evans; S. F. Heinemann

Chromosomal localization of human glutamate receptor genes

J. O. McNamara, J. H. Eubanks, John Douglas Mcpherson, J. J. Wasmuth, G. A. Evans, S. F. Heinemann

Research output: Contribution to journal › Article › peer-review

Abstract

The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

Original language	English (US)
Pages (from-to)	2555-2562
Number of pages	8
Journal	Journal of Neuroscience
Volume	12
Issue number	7
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

Fingerprint Dive into the research topics of 'Chromosomal localization of human glutamate receptor genes'. Together they form a unique fingerprint.

Cite this

@article{42d932979e86426f98e1b22444cfb6bd,

title = "Chromosomal localization of human glutamate receptor genes",

abstract = "The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.",

author = "McNamara, {J. O.} and Eubanks, {J. H.} and Mcpherson, {John Douglas} and Wasmuth, {J. J.} and Evans, {G. A.} and Heinemann, {S. F.}",

year = "1992",

language = "English (US)",

volume = "12",

pages = "2555--2562",

journal = "Journal of Neuroscience",

issn = "0270-6474",

publisher = "Society for Neuroscience",

number = "7",

}

TY - JOUR

T1 - Chromosomal localization of human glutamate receptor genes

AU - McNamara, J. O.

AU - Eubanks, J. H.

AU - Mcpherson, John Douglas

AU - Wasmuth, J. J.

AU - Evans, G. A.

AU - Heinemann, S. F.

PY - 1992

Y1 - 1992

N2 - The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

AB - The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

UR - http://www.scopus.com/inward/record.url?scp=0026632494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026632494&partnerID=8YFLogxK

M3 - Article

C2 - 1319477

AN - SCOPUS:0026632494

VL - 12

SP - 2555

EP - 2562

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 7

ER -