Chromosomal localization of human glutamate receptor genes

J. O. McNamara, J. H. Eubanks, John Douglas Mcpherson, J. J. Wasmuth, G. A. Evans, S. F. Heinemann

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

Original languageEnglish (US)
Pages (from-to)2555-2562
Number of pages8
JournalJournal of Neuroscience
Volume12
Issue number7
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    McNamara, J. O., Eubanks, J. H., Mcpherson, J. D., Wasmuth, J. J., Evans, G. A., & Heinemann, S. F. (1992). Chromosomal localization of human glutamate receptor genes. Journal of Neuroscience, 12(7), 2555-2562.