Chromosomal localization of human glutamate receptor genes

J. O. McNamara; J. H. Eubanks; John Douglas Mcpherson; J. J. Wasmuth; G. A. Evans; S. F. Heinemann

Chromosomal localization of human glutamate receptor genes

J. O. McNamara, J. H. Eubanks, John Douglas Mcpherson, J. J. Wasmuth, G. A. Evans, S. F. Heinemann

Research output: Contribution to journal › Article

Abstract

The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

Original language	English (US)
Pages (from-to)	2555-2562
Number of pages	8
Journal	Journal of Neuroscience
Volume	12
Issue number	7
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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McNamara, J. O., Eubanks, J. H., Mcpherson, J. D., Wasmuth, J. J., Evans, G. A., & Heinemann, S. F. (1992). Chromosomal localization of human glutamate receptor genes. Journal of Neuroscience, 12(7), 2555-2562.

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title = "Chromosomal localization of human glutamate receptor genes",

abstract = "The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.",

author = "McNamara, {J. O.} and Eubanks, {J. H.} and Mcpherson, {John Douglas} and Wasmuth, {J. J.} and Evans, {G. A.} and Heinemann, {S. F.}",

year = "1992",

language = "English (US)",

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pages = "2555--2562",

journal = "Journal of Neuroscience",

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T1 - Chromosomal localization of human glutamate receptor genes

AU - McNamara, J. O.

AU - Eubanks, J. H.

AU - Mcpherson, John Douglas

AU - Wasmuth, J. J.

AU - Evans, G. A.

AU - Heinemann, S. F.

PY - 1992

Y1 - 1992

N2 - The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

AB - The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22- 23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral- renal syndrome of Lowe and a form of manic-depressive illness.

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