Choroid plexus tumors in 56 dogs (1985-2007)

D. R. Westworth, Peter J Dickinson, William Vernau, Eric G Johnson, A. W. Bollen, Philip H Kass, Beverly Sturges, Karen Vernau, Richard A Lecouteur, Robert Higgins

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: Choroid plexus tumors (CPTs) comprise approximately 10% of all primary brain tumors in dogs. The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined. Objectives: To report MRI and CSF findings in dogs with CPT and determine if there are distinguishing features that allow clinical discrimination between the tumor grades. Animals: Fifty-six client-owned dogs with naturally occurring CPT. Methods: Retrospective case series. The inclusion criterion was histologically confirmed CPT. Blinded review of cranial MRI and cisternal CSF analysis was performed. Results: Thirty-six of 56 dogs had a choroid plexus carcinoma (CPC) and 20 had a choroid plexus papilloma (CPP). Golden Retrievers were overrepresented compared with the hospital population (frequency 3.7 times that expected, confidence interval 95% = 2.0-6.7, P < .0002). Median CSF protein concentration in CPCs (108mg/dL, range 27-380mg/dL) was significantly higher than in CPPs (34mg/dL, range 32-80 mg/dL) (P = .002). Only dogs with CPCs had a CSF protein concentration > 80 mg/dL. Cytological evidence of malignancy in CSF was seen in 7 of 15 CPCs. Only CPCs had evidence of intraventricular or subarachnoid metastases on MRI. Conclusions and Clinical Importance: MRI, CSF analysis or both can help to differentiate between CPPs and CPCs, and may provide valuable prognostic and pretreatment information.

Original languageEnglish (US)
Pages (from-to)1157-1165
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume22
Issue number5
DOIs
StatePublished - Sep 2008

Fingerprint

Choroid Plexus Neoplasms
choroid plexus
Cerebrospinal Fluid
cerebrospinal fluid
Magnetic Resonance Imaging
Dogs
magnetic resonance imaging
neoplasms
dogs
Choroid Plexus Papilloma
Brain Neoplasms
Golden Retriever
papilloma
Neoplasms
Confidence Intervals
Neoplasm Metastasis
metastasis
carcinoma
confidence interval
pretreatment

Keywords

  • Canine
  • Cerebrospinal fluid
  • Choroid plexus carcinoma
  • Choroid plexus papilloma
  • Magnetic resonance imaging
  • WHO tumor classification

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Choroid plexus tumors in 56 dogs (1985-2007). / Westworth, D. R.; Dickinson, Peter J; Vernau, William; Johnson, Eric G; Bollen, A. W.; Kass, Philip H; Sturges, Beverly; Vernau, Karen; Lecouteur, Richard A; Higgins, Robert.

In: Journal of Veterinary Internal Medicine, Vol. 22, No. 5, 09.2008, p. 1157-1165.

Research output: Contribution to journalArticle

@article{6822f48b43a74a548d4c405065841bbf,
title = "Choroid plexus tumors in 56 dogs (1985-2007)",
abstract = "Background: Choroid plexus tumors (CPTs) comprise approximately 10{\%} of all primary brain tumors in dogs. The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined. Objectives: To report MRI and CSF findings in dogs with CPT and determine if there are distinguishing features that allow clinical discrimination between the tumor grades. Animals: Fifty-six client-owned dogs with naturally occurring CPT. Methods: Retrospective case series. The inclusion criterion was histologically confirmed CPT. Blinded review of cranial MRI and cisternal CSF analysis was performed. Results: Thirty-six of 56 dogs had a choroid plexus carcinoma (CPC) and 20 had a choroid plexus papilloma (CPP). Golden Retrievers were overrepresented compared with the hospital population (frequency 3.7 times that expected, confidence interval 95{\%} = 2.0-6.7, P < .0002). Median CSF protein concentration in CPCs (108mg/dL, range 27-380mg/dL) was significantly higher than in CPPs (34mg/dL, range 32-80 mg/dL) (P = .002). Only dogs with CPCs had a CSF protein concentration > 80 mg/dL. Cytological evidence of malignancy in CSF was seen in 7 of 15 CPCs. Only CPCs had evidence of intraventricular or subarachnoid metastases on MRI. Conclusions and Clinical Importance: MRI, CSF analysis or both can help to differentiate between CPPs and CPCs, and may provide valuable prognostic and pretreatment information.",
keywords = "Canine, Cerebrospinal fluid, Choroid plexus carcinoma, Choroid plexus papilloma, Magnetic resonance imaging, WHO tumor classification",
author = "Westworth, {D. R.} and Dickinson, {Peter J} and William Vernau and Johnson, {Eric G} and Bollen, {A. W.} and Kass, {Philip H} and Beverly Sturges and Karen Vernau and Lecouteur, {Richard A} and Robert Higgins",
year = "2008",
month = "9",
doi = "10.1111/j.1939-1676.2008.0170.x",
language = "English (US)",
volume = "22",
pages = "1157--1165",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Choroid plexus tumors in 56 dogs (1985-2007)

AU - Westworth, D. R.

AU - Dickinson, Peter J

AU - Vernau, William

AU - Johnson, Eric G

AU - Bollen, A. W.

AU - Kass, Philip H

AU - Sturges, Beverly

AU - Vernau, Karen

AU - Lecouteur, Richard A

AU - Higgins, Robert

PY - 2008/9

Y1 - 2008/9

N2 - Background: Choroid plexus tumors (CPTs) comprise approximately 10% of all primary brain tumors in dogs. The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined. Objectives: To report MRI and CSF findings in dogs with CPT and determine if there are distinguishing features that allow clinical discrimination between the tumor grades. Animals: Fifty-six client-owned dogs with naturally occurring CPT. Methods: Retrospective case series. The inclusion criterion was histologically confirmed CPT. Blinded review of cranial MRI and cisternal CSF analysis was performed. Results: Thirty-six of 56 dogs had a choroid plexus carcinoma (CPC) and 20 had a choroid plexus papilloma (CPP). Golden Retrievers were overrepresented compared with the hospital population (frequency 3.7 times that expected, confidence interval 95% = 2.0-6.7, P < .0002). Median CSF protein concentration in CPCs (108mg/dL, range 27-380mg/dL) was significantly higher than in CPPs (34mg/dL, range 32-80 mg/dL) (P = .002). Only dogs with CPCs had a CSF protein concentration > 80 mg/dL. Cytological evidence of malignancy in CSF was seen in 7 of 15 CPCs. Only CPCs had evidence of intraventricular or subarachnoid metastases on MRI. Conclusions and Clinical Importance: MRI, CSF analysis or both can help to differentiate between CPPs and CPCs, and may provide valuable prognostic and pretreatment information.

AB - Background: Choroid plexus tumors (CPTs) comprise approximately 10% of all primary brain tumors in dogs. The clinical utility of magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, or both in the presumptive diagnosis of CPTs has not been determined. Objectives: To report MRI and CSF findings in dogs with CPT and determine if there are distinguishing features that allow clinical discrimination between the tumor grades. Animals: Fifty-six client-owned dogs with naturally occurring CPT. Methods: Retrospective case series. The inclusion criterion was histologically confirmed CPT. Blinded review of cranial MRI and cisternal CSF analysis was performed. Results: Thirty-six of 56 dogs had a choroid plexus carcinoma (CPC) and 20 had a choroid plexus papilloma (CPP). Golden Retrievers were overrepresented compared with the hospital population (frequency 3.7 times that expected, confidence interval 95% = 2.0-6.7, P < .0002). Median CSF protein concentration in CPCs (108mg/dL, range 27-380mg/dL) was significantly higher than in CPPs (34mg/dL, range 32-80 mg/dL) (P = .002). Only dogs with CPCs had a CSF protein concentration > 80 mg/dL. Cytological evidence of malignancy in CSF was seen in 7 of 15 CPCs. Only CPCs had evidence of intraventricular or subarachnoid metastases on MRI. Conclusions and Clinical Importance: MRI, CSF analysis or both can help to differentiate between CPPs and CPCs, and may provide valuable prognostic and pretreatment information.

KW - Canine

KW - Cerebrospinal fluid

KW - Choroid plexus carcinoma

KW - Choroid plexus papilloma

KW - Magnetic resonance imaging

KW - WHO tumor classification

UR - http://www.scopus.com/inward/record.url?scp=52649130254&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649130254&partnerID=8YFLogxK

U2 - 10.1111/j.1939-1676.2008.0170.x

DO - 10.1111/j.1939-1676.2008.0170.x

M3 - Article

C2 - 18691364

AN - SCOPUS:52649130254

VL - 22

SP - 1157

EP - 1165

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 5

ER -