Abstract
Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2347-2354 |
| Number of pages | 8 |
| Journal | Life Sciences |
| Volume | 38 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jun 23 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Cholinergic induction of seizures in the rat prefrontal cortex. / Crawley, Jacqueline; Stivers, Jill A.; Martin, Joseph V.; Mendelson, Wallace B.
In: Life Sciences, Vol. 38, No. 25, 23.06.1986, p. 2347-2354.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cholinergic induction of seizures in the rat prefrontal cortex
AU - Crawley, Jacqueline
AU - Stivers, Jill A.
AU - Martin, Joseph V.
AU - Mendelson, Wallace B.
PY - 1986/6/23
Y1 - 1986/6/23
N2 - Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.
AB - Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022536508&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(86)90642-9
DO - 10.1016/0024-3205(86)90642-9
M3 - Article
C2 - 3724361
AN - SCOPUS:0022536508
VL - 38
SP - 2347
EP - 2354
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 25
ER -