Cholinergic induction of seizures in the rat prefrontal cortex

Jacqueline Crawley, Jill A. Stivers, Joseph V. Martin, Wallace B. Mendelson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.

Original languageEnglish (US)
Pages (from-to)2347-2354
Number of pages8
JournalLife Sciences
Volume38
Issue number25
DOIs
StatePublished - Jun 23 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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