Choline esters in the marine gastropods Nucella emarginata and Acanthina spirata: A new choline ester, tentatively identified as N-methylmurexine

Jeanne A. Bender, Kathryn DeRiemer, Thomas E. Roberts, Robert Rushton, Paul Boothe, Harry S. Mosher, Frederick A. Fuhrman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Abstract1.Several tissues of two intertidal gastropod mollusks belonging to the superfamily Muricacea contained, in addition to acetylcholine, other choline esters that produced contraction of the frog rectus abdominis muscle.2.One major active choline ester found in acetone extracts of the hypobranchial gland of Acanthina spirata had pharmacological properties and a nuclear magnetic resonance spectrum consistent with murexine [urocanylcholine, β-[4-imidazolyl]acrylcholine).3.A principal active compound from the hypobranchial gland of Nucella ( = Thais) emarginata differed pharmacologically from murexine and was tentatively identified by nuclear magnetic resonance spectroscopy as the previously unreported N-methyl derivative of murexine, β-[4-(1-or 3-methyl)-imidazolyl]acrylcholine.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalComparative and General Pharmacology
Volume5
Issue number3-4
DOIs
StatePublished - 1974
Externally publishedYes

Keywords

  • Acanthina spirata
  • choline esters
  • marine gastropods
  • mollusks
  • murexine
  • N-methyl-murexine
  • Nucella emarginata
  • urocanylcholine (β-[4-imidazolyl] acrylcholine)
  • β-4-(1- or 3-methyl)-imidazolyl acrylcholine

ASJC Scopus subject areas

  • Pharmacology

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