Cholestasis of pregnancy: A review of the evidence

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Intrahepatic cholestasis of pregnancy is a rare disorder, predominately occurring during the third trimester of pregnancy and characterized by pruritis, jaundice, and biochemical disturbances in liver enzymes. While intrahepatic cholestasis of pregnancy poses little maternal risk, there is significant risk to the fetus such as preterm delivery, nonreassuring fetal status, meconium staining, and perinatal mortality. Current evidence proposes susceptibility to derangements in the sulfation of steroid compounds, affecting the metabolism of progesterone and bile acids in the fetal/placental compartment. Treatment with ursodeoxycholic acid is suggested, coupled with close maternal-fetal surveillance and delivery as close to term as possible.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalJournal of Perinatal and Neonatal Nursing
Volume19
Issue number3
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Cholestasis
Mothers
Ursodeoxycholic Acid
Pregnancy
Meconium
Fetal Distress
Perinatal Mortality
Third Pregnancy Trimester
Pruritus
Jaundice
Bile Acids and Salts
Progesterone
Fetus
Steroids
Staining and Labeling
Liver
Enzymes
Intrahepatic Cholestasis of Pregnancy

Keywords

  • Cholestasis
  • Fetal compromise
  • Jaundice
  • Pregnancy

ASJC Scopus subject areas

  • Pediatrics
  • Critical Care
  • Maternity and Midwifery

Cite this

Cholestasis of pregnancy : A review of the evidence. / Nichols, Amy.

In: Journal of Perinatal and Neonatal Nursing, Vol. 19, No. 3, 01.01.2005, p. 217-225.

Research output: Contribution to journalReview article

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