Abstract
The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.
Original language | English (US) |
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Pages (from-to) | 407-411 |
Number of pages | 5 |
Journal | Physiology and Behavior |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
Keywords
- Cholecystokinin
- Exploratory behavior
- Mouse behavior
- Neuropeptides
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience