Abstract
The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 407-411 |
| Number of pages | 5 |
| Journal | Physiology and Behavior |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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Keywords
- Cholecystokinin
- Exploratory behavior
- Mouse behavior
- Neuropeptides
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience
Cite this
Cholecystokinin reduces exploratory behavior in mice. / Crawley, Jacqueline; Hays, Sally E.; Paul, Steven M.; Goodwin, Frederick K.
In: Physiology and Behavior, Vol. 27, No. 3, 1981, p. 407-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cholecystokinin reduces exploratory behavior in mice
AU - Crawley, Jacqueline
AU - Hays, Sally E.
AU - Paul, Steven M.
AU - Goodwin, Frederick K.
PY - 1981
Y1 - 1981
N2 - The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.
AB - The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.
KW - Cholecystokinin
KW - Exploratory behavior
KW - Mouse behavior
KW - Neuropeptides
UR - http://www.scopus.com/inward/record.url?scp=0019781087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019781087&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(81)90324-3
DO - 10.1016/0031-9384(81)90324-3
M3 - Article
C2 - 6278520
AN - SCOPUS:0019781087
VL - 27
SP - 407
EP - 411
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 3
ER -