Cholecystokinin reduces exploratory behavior in mice

Jacqueline Crawley; Sally E. Hays; Steven M. Paul; Frederick K. Goodwin

doi:10.1016/0031-9384(81)90324-3

Cholecystokinin reduces exploratory behavior in mice

Jacqueline Crawley, Sally E. Hays, Steven M. Paul, Frederick K. Goodwin

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin₈ changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.

Original language	English (US)
Pages (from-to)	407-411
Number of pages	5
Journal	Physiology and Behavior
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0031-9384(81)90324-3
State	Published - 1981
Externally published	Yes

Keywords

Cholecystokinin
Exploratory behavior
Mouse behavior
Neuropeptides

ASJC Scopus subject areas

Physiology (medical)
Behavioral Neuroscience

Access to Document

10.1016/0031-9384(81)90324-3

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title = "Cholecystokinin reduces exploratory behavior in mice",

abstract = "The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.",

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AU - Crawley, Jacqueline

AU - Hays, Sally E.

AU - Paul, Steven M.

AU - Goodwin, Frederick K.

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