Abstract
CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-292 |
| Number of pages | 10 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | VOL. 448 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Cholecystokinin potentiation of dopamine-mediated behaviors in the nucleus accumbens. / Crawley, Jacqueline.
In: Annals of the New York Academy of Sciences, Vol. VOL. 448, 1985, p. 283-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cholecystokinin potentiation of dopamine-mediated behaviors in the nucleus accumbens
AU - Crawley, Jacqueline
PY - 1985
Y1 - 1985
N2 - CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.
AB - CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022271288&partnerID=8YFLogxK
M3 - Article
VL - VOL. 448
SP - 283
EP - 292
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -