Cholecystokinin potentiation of dopamine-mediated behaviors in the nucleus accumbens

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalAnnals of the New York Academy of Sciences
VolumeVOL. 448
StatePublished - 1985
Externally publishedYes

Fingerprint

Apomorphine
Caudate Nucleus
Cholecystokinin
Nucleus Accumbens
Neuropeptides
Catecholamines
Neurotransmitter Agents
Rats
Dopamine
Modulation
Peptides
Catalytic Domain
Nucleus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{62b5ea1b89ed4b7d8d98aabe17164a7c,
title = "Cholecystokinin potentiation of dopamine-mediated behaviors in the nucleus accumbens",
abstract = "CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.",
author = "Jacqueline Crawley",
year = "1985",
language = "English (US)",
volume = "VOL. 448",
pages = "283--292",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Cholecystokinin potentiation of dopamine-mediated behaviors in the nucleus accumbens

AU - Crawley, Jacqueline

PY - 1985

Y1 - 1985

N2 - CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.

AB - CCK potentiated dopamine- and apomorphine-mediated locomotor and stereotypic behaviors in the nucleus accumbens, but had no effect in the caudate nucleus. The distribution of active sites for behavioral effects parallels the anatomical distribution of co-existing CCK-DA terminal regions. The specificity of CCK in potentiating DA-induced behaviors in the nucleus accumbens, but not in the caudate nucleus, is consistent with the hypothesis that the potentiation phenomenon may be related to the synaptic organization of a co-existing peptide and catecholamine. Possible mechanisms of interaction include modulation at the level of interacting release sites, and, interacting postsynaptic receptor subunits. The CCK-DA co-existence in the mesolimbic pathway of the rat may provide a prototypic model system for delineating the mechanisms by which a neuropeptide modulates a neurotransmitter.

UR - http://www.scopus.com/inward/record.url?scp=0022271288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022271288&partnerID=8YFLogxK

M3 - Article

C2 - 3861122

AN - SCOPUS:0022271288

VL - VOL. 448

SP - 283

EP - 292

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -