Abstract
Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 523-527 |
| Number of pages | 5 |
| Journal | Psychopharmacology Bulletin |
| Volume | 21 |
| Issue number | 3 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology
Cite this
Cholecystokinin potentiates dopamine-mediated behaviors in the nucleus accumbens, a site of CCK-DA co-existence. / Crawley, Jacqueline.
In: Psychopharmacology Bulletin, Vol. 21, No. 3, 1985, p. 523-527.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cholecystokinin potentiates dopamine-mediated behaviors in the nucleus accumbens, a site of CCK-DA co-existence
AU - Crawley, Jacqueline
PY - 1985
Y1 - 1985
N2 - Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.
AB - Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022342204&partnerID=8YFLogxK
M3 - Article
C2 - 4034868
AN - SCOPUS:0022342204
VL - 21
SP - 523
EP - 527
JO - Psychopharmacology Bulletin
JF - Psychopharmacology Bulletin
SN - 0048-5764
IS - 3
ER -