Cholecystokinin potentiates dopamine-mediated behaviors in the nucleus accumbens, a site of CCK-DA co-existence

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Abstract

Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.

Original languageEnglish (US)
Pages (from-to)523-527
Number of pages5
JournalPsychopharmacology Bulletin
Volume21
Issue number3
StatePublished - 1985
Externally publishedYes

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Cholecystokinin
Nucleus Accumbens
Dopamine
Apomorphine
Amino Acids
Peptides
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

Cite this

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title = "Cholecystokinin potentiates dopamine-mediated behaviors in the nucleus accumbens, a site of CCK-DA co-existence",
abstract = "Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.",
author = "Jacqueline Crawley",
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T1 - Cholecystokinin potentiates dopamine-mediated behaviors in the nucleus accumbens, a site of CCK-DA co-existence

AU - Crawley, Jacqueline

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N2 - Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.

AB - Cholecystokinin is an eight-amino acid peptide found in mammalian brain and gut. Recent immunocytochemical studies demonstrated colocalization of cholecystokinin (CCK) and dopamine (DA) in the mesolimbic pathway of the rat. To test the behavioral significance of the CCK-DA co-existence, we have microinfused CCK into the nucleus accumbens, alone or in combination with DA or apomorphine, and measured two standard dopaminergic behaviors, hyperlocomotion and stereotypy in rats. The data summarized above support the conclusion that CCK acts as a modulator of DA in the nucleus accumbens, since CCK had no effect when administered alone, but potentiated the behavioral effects of DA and apomorphine.

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