Cholecystokinin potentiates dopamine-mediated behaviors: Evidence for modulation specific to a site of coexistence

Jacqueline Crawley, J. A. Stivers, L. K. Blumstein, S. M. Paul

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Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or stereotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon.

Original languageEnglish (US)
Pages (from-to)1972-1983
Number of pages12
JournalJournal of Neuroscience
Issue number8
StatePublished - 1985
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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