Cholecystokinin potentiates dopamine-mediated behaviors: Evidence for modulation specific to a site of coexistence

Jacqueline Crawley, J. A. Stivers, L. K. Blumstein, S. M. Paul

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or stereotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon.

Original languageEnglish (US)
Pages (from-to)1972-1983
Number of pages12
JournalJournal of Neuroscience
Volume5
Issue number8
StatePublished - 1985
Externally publishedYes

Fingerprint

Cholecystokinin
Dopamine
Apomorphine
Neurotransmitter Agents
Proglumide
Neurons
Caudate Nucleus
Nucleus Accumbens
Locomotion
Immune Sera
Peptides
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cholecystokinin potentiates dopamine-mediated behaviors : Evidence for modulation specific to a site of coexistence. / Crawley, Jacqueline; Stivers, J. A.; Blumstein, L. K.; Paul, S. M.

In: Journal of Neuroscience, Vol. 5, No. 8, 1985, p. 1972-1983.

Research output: Contribution to journalArticle

@article{e32fbfc4a1bc4e948af811a91a273e55,
title = "Cholecystokinin potentiates dopamine-mediated behaviors: Evidence for modulation specific to a site of coexistence",
abstract = "Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or stereotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon.",
author = "Jacqueline Crawley and Stivers, {J. A.} and Blumstein, {L. K.} and Paul, {S. M.}",
year = "1985",
language = "English (US)",
volume = "5",
pages = "1972--1983",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "8",

}

TY - JOUR

T1 - Cholecystokinin potentiates dopamine-mediated behaviors

T2 - Evidence for modulation specific to a site of coexistence

AU - Crawley, Jacqueline

AU - Stivers, J. A.

AU - Blumstein, L. K.

AU - Paul, S. M.

PY - 1985

Y1 - 1985

N2 - Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or stereotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon.

AB - Cholecystokinin coexists with dopamine in mesolimbic neurons in mammalian brain. When injected directly into the nucleus accumbens, cholecystokinin (CCK) potentiated dopamine (DA)-induced hyperlocomotion and apomorphine-induced stereotypy. These effects were not mimicked by nonsulfated CCK, but were blocked by proglumide, a putative CCK antagonist, as well as by antisera raised against sulfated CCK. CCK alone had no effect on locomotion or stereotypy, indicating that this peptide acts primarily as a modulator of DA-mediated behaviors in the mesolimbic pathway. In addition, CCK did not potentiate DA-induced hyperlocomotion or apomorphine-induced stereotypy when injected into the caudate nucleus, where CCK and DA are localized in separate neurons in rats. Facilitation of DA-mediated behaviors by CCK may represent a functional interaction specific to the neuromodulator-neurotransmitter coexistence phenomenon.

UR - http://www.scopus.com/inward/record.url?scp=0022263953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022263953&partnerID=8YFLogxK

M3 - Article

C2 - 4040554

AN - SCOPUS:0022263953

VL - 5

SP - 1972

EP - 1983

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 8

ER -