Chloride secretion and function of serous and mucous cells of human airway glands

W. E. Finkbeiner, B. Q. Shen, Jonathan Widdicombe

Research output: Contribution to journalArticle

Abstract

Cells from the acini of human tracheal glands were grown in culture to produce confluent cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis transmembrane conductance regulator (an apical membrane Cl channel) were also much less in mucous than in seromucous cells. These results suggest that serous cells are more important than mucous cells in providing the fluid component of gland secretions.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume267
Issue number2 11-2
StatePublished - 1994
Externally publishedYes

Fingerprint

Chlorides
Orosomucoid
Cystic Fibrosis Transmembrane Conductance Regulator
Acinar Cells
Ion Channels
Phenotype

Keywords

  • cystic fibrosis
  • cystic fibrosis transmembrane conductance regulator
  • Ussing chambers

ASJC Scopus subject areas

  • Cell Biology
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Chloride secretion and function of serous and mucous cells of human airway glands. / Finkbeiner, W. E.; Shen, B. Q.; Widdicombe, Jonathan.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 267, No. 2 11-2, 1994.

Research output: Contribution to journalArticle

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