Chlorambucil treatment of frequently relapsing nephrotic syndrome

W. E. Grupe, Sudesh P Makker, J. R. Ingelfinger

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76 Scopus citations


Chlorambucil, in combination with prednisone, was compared with prednisone alone in a randomized controlled trial in 21 children with either steroid dependent or frequently relapsing nephrotic syndrome to assess its effect on the duration of remission and the rate of relapse. All control patients treated with prednisone alone continued to relapse at the same rate, with all patients experiencing a return of proteinuria by seven months. Conversely, those who received the same prednisone therapy along with chlorambucil for six to 12 weeks remained in complete remission, without further medication, during 12 to 34 months of followup observation. Complications were minimal. Immediate side effects commonly reported with cyclophosphamide were not seen with chlorambucil. Comparison with published reports also suggests that remission induced by chlorambucil is more stable than that after cyclophosphamide. Chlorambucil appears to be of value in the frequently relapsing nephrotic patient, adding an effect that is unattainable with prednisone alone.

Original languageEnglish (US)
Pages (from-to)746-749
Number of pages4
JournalNew England Journal of Medicine
Issue number14
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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