Chitosan supplementation and fat absorption in men and women

Matthew D. Gades, Judith S. Stern

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Chitosan is a primary ingredient in dietary weight-loss supplements. Its claimed activity is the binding and trapping of dietary fat, leading to fat excretion and weight loss without caloric restriction. We tested the fat-trapping capacity of a chitosan product in men and women. Participants (12 men, 12 women) were instructed to follow customized diet plans (five meals/day for 12 days). Oral charcoal markers defined two 4-day experimental periods. Two capsules were taken five times per day before each meal during the supplement period (2.5 g chitosan/day) and not during the control period. Feces were collected from day 2 to day 12. Feces from each period were pooled and analyzed for fat content. For men (mean±standard deviation=24.8±5.1 years, body mass index [BMI; calculated as kg/m 2] 26.6±4.5) the average daily was 137±31 g fat and 3,256±624 kcal. For women (23.3±5.0 years, BMI 24.1±3.5) average daily 89±16 g fat and 2,110±195 kcal. Each two-capsule dose was consumed with 28±11 g fat in males and 18±7 g in females (range =10-76 g/dose). Fecal fat excretion increased with chitosan by 1.8±2.4 g/day in males, P=.02, and did not increase with chitosan (0.0±1.4 g/day, P=.99) in females. The fat trapped was clinically insignificant. For men, it would take more than 7 months to lose 1 pound of body fat. For women, no fat was trapped. This product, as with other similar products, fails to meet claims.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalJournal of the American Dietetic Association
Volume105
Issue number1
DOIs
StatePublished - Jan 2005

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Chitosan
chitosan
Fats
lipids
trapping
Feces
Capsules
weight loss
Meals
excretion
Weight Loss
feces
Caloric Restriction
dosage
charcoal
Charcoal
Dietary Fats
dietary fat
body fat
body mass index

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

Cite this

Chitosan supplementation and fat absorption in men and women. / Gades, Matthew D.; Stern, Judith S.

In: Journal of the American Dietetic Association, Vol. 105, No. 1, 01.2005, p. 72-77.

Research output: Contribution to journalArticle

Gades, Matthew D. ; Stern, Judith S. / Chitosan supplementation and fat absorption in men and women. In: Journal of the American Dietetic Association. 2005 ; Vol. 105, No. 1. pp. 72-77.
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