Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates

Aijun Wang, Q. Ao, K. Gong, Z. H. Zheng, G. Y. Lu, G. Wang, Q. He, L. J. Kong, Y. D. Gong, N. M. Zhao, X. F. Zhang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Goats and nonhuman primates were used as animal models to evaluate the effectiveness of the chitosan conduits in bridging longer peripheral nerve defects. All animals were monitored for changes in their appearance, gait and locomotion activities after surgery. Sixteen months post-operatively, functional reinnervation of motor and sensory nerves was investigated by electrophysiological examination including compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). Histological assessment and morphometric analyses to regenerated nerves were used to investigate the nerve repair effects of the conduits. Results confirm the feasibility of the chitosan nerve conduits for peripheral nerve regeneration in large animal models.

Original languageEnglish (US)
Pages (from-to)143-144
Number of pages2
JournalMCB Molecular and Cellular Biomechanics
Volume3
Issue number4
StatePublished - Dec 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology
  • Biophysics
  • Molecular Biology
  • Molecular Medicine

Cite this

Wang, A., Ao, Q., Gong, K., Zheng, Z. H., Lu, G. Y., Wang, G., He, Q., Kong, L. J., Gong, Y. D., Zhao, N. M., & Zhang, X. F. (2006). Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates. MCB Molecular and Cellular Biomechanics, 3(4), 143-144.