Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates

Aijun Wang, Q. Ao, K. Gong, Z. H. Zheng, G. Y. Lu, G. Wang, Q. He, L. J. Kong, Y. D. Gong, N. M. Zhao, X. F. Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Goats and nonhuman primates were used as animal models to evaluate the effectiveness of the chitosan conduits in bridging longer peripheral nerve defects. All animals were monitored for changes in their appearance, gait and locomotion activities after surgery. Sixteen months post-operatively, functional reinnervation of motor and sensory nerves was investigated by electrophysiological examination including compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). Histological assessment and morphometric analyses to regenerated nerves were used to investigate the nerve repair effects of the conduits. Results confirm the feasibility of the chitosan nerve conduits for peripheral nerve regeneration in large animal models.

Original languageEnglish (US)
Pages (from-to)143-144
Number of pages2
JournalMCB Molecular and Cellular Biomechanics
Volume3
Issue number4
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Nerve Regeneration
Chitosan
Peripheral Nerves
Goats
Primates
Animal Models
Somatosensory Evoked Potentials
Locomotion
Gait
Action Potentials
Muscles

ASJC Scopus subject areas

  • Cell Biology
  • Biophysics
  • Molecular Biology
  • Molecular Medicine

Cite this

Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates. / Wang, Aijun; Ao, Q.; Gong, K.; Zheng, Z. H.; Lu, G. Y.; Wang, G.; He, Q.; Kong, L. J.; Gong, Y. D.; Zhao, N. M.; Zhang, X. F.

In: MCB Molecular and Cellular Biomechanics, Vol. 3, No. 4, 12.2006, p. 143-144.

Research output: Contribution to journalArticle

Wang, A, Ao, Q, Gong, K, Zheng, ZH, Lu, GY, Wang, G, He, Q, Kong, LJ, Gong, YD, Zhao, NM & Zhang, XF 2006, 'Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates', MCB Molecular and Cellular Biomechanics, vol. 3, no. 4, pp. 143-144.
Wang, Aijun ; Ao, Q. ; Gong, K. ; Zheng, Z. H. ; Lu, G. Y. ; Wang, G. ; He, Q. ; Kong, L. J. ; Gong, Y. D. ; Zhao, N. M. ; Zhang, X. F. / Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates. In: MCB Molecular and Cellular Biomechanics. 2006 ; Vol. 3, No. 4. pp. 143-144.
@article{db1ab0a954544dbb9bc47a1c99642a70,
title = "Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates",
abstract = "Goats and nonhuman primates were used as animal models to evaluate the effectiveness of the chitosan conduits in bridging longer peripheral nerve defects. All animals were monitored for changes in their appearance, gait and locomotion activities after surgery. Sixteen months post-operatively, functional reinnervation of motor and sensory nerves was investigated by electrophysiological examination including compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). Histological assessment and morphometric analyses to regenerated nerves were used to investigate the nerve repair effects of the conduits. Results confirm the feasibility of the chitosan nerve conduits for peripheral nerve regeneration in large animal models.",
author = "Aijun Wang and Q. Ao and K. Gong and Zheng, {Z. H.} and Lu, {G. Y.} and G. Wang and Q. He and Kong, {L. J.} and Gong, {Y. D.} and Zhao, {N. M.} and Zhang, {X. F.}",
year = "2006",
month = "12",
language = "English (US)",
volume = "3",
pages = "143--144",
journal = "MCB Molecular and Cellular Biomechanics",
issn = "1556-5297",
publisher = "Tech Science Press",
number = "4",

}

TY - JOUR

T1 - Chitosan-based semi-permeable nerve conduits support periphereal nerve regeneration in goats and nonhuman primates

AU - Wang, Aijun

AU - Ao, Q.

AU - Gong, K.

AU - Zheng, Z. H.

AU - Lu, G. Y.

AU - Wang, G.

AU - He, Q.

AU - Kong, L. J.

AU - Gong, Y. D.

AU - Zhao, N. M.

AU - Zhang, X. F.

PY - 2006/12

Y1 - 2006/12

N2 - Goats and nonhuman primates were used as animal models to evaluate the effectiveness of the chitosan conduits in bridging longer peripheral nerve defects. All animals were monitored for changes in their appearance, gait and locomotion activities after surgery. Sixteen months post-operatively, functional reinnervation of motor and sensory nerves was investigated by electrophysiological examination including compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). Histological assessment and morphometric analyses to regenerated nerves were used to investigate the nerve repair effects of the conduits. Results confirm the feasibility of the chitosan nerve conduits for peripheral nerve regeneration in large animal models.

AB - Goats and nonhuman primates were used as animal models to evaluate the effectiveness of the chitosan conduits in bridging longer peripheral nerve defects. All animals were monitored for changes in their appearance, gait and locomotion activities after surgery. Sixteen months post-operatively, functional reinnervation of motor and sensory nerves was investigated by electrophysiological examination including compound muscle action potential (CMAP) and somatosensory evoked potential (SEP). Histological assessment and morphometric analyses to regenerated nerves were used to investigate the nerve repair effects of the conduits. Results confirm the feasibility of the chitosan nerve conduits for peripheral nerve regeneration in large animal models.

UR - http://www.scopus.com/inward/record.url?scp=33846418768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846418768&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33846418768

VL - 3

SP - 143

EP - 144

JO - MCB Molecular and Cellular Biomechanics

JF - MCB Molecular and Cellular Biomechanics

SN - 1556-5297

IS - 4

ER -