Chiral analyses of peptides by ion/molecule reactions

Gabriela Grigorean, Xin Cong, Carlito B Lebrilla

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Protonated complexes comprised of guest peptides with permethylated hosts (β-cyclodextrin and maltoheptaose) were produced in the gas phase by electrospray ionization and reacted with a gaseous amine in a Fourier transform ion cyclotron resonance mass spectrometer. An exchange reaction was observed whereby the guest peptide was replaced by the gaseous alkyl amine. The exchange reaction was enantioselective and was used to determine enantiomeric excess in mixtures of enantiomers. The nature of the recognition is probed by the selection of the peptides and the use of molecular dynamics calculations.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalInternational Journal of Mass Spectrometry
Volume234
Issue number1-3
DOIs
StatePublished - May 1 2004

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Keywords

  • Chiral analyses
  • Ion/molecule reactions
  • Peptides

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy

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