Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory

Ling M. Wong, Tracy Riggins, Danielle J Harvey, Margarita Cabaral, Tony J Simon

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) have been shown to have impairments in processing spatiotemporal information. The authors examined whether children with 22q11.2DS exhibit impairments in spatial working memory performance due to these weaknesses, even when controlling for maintenance of attention. Children with 22q11.2DS (n 5 47) and typically developing controls (n 5 49) ages 6-15 years saw images within a grid and after a delay, then indicated the positions of the images in the correct temporal order. Children with 22q11.2DS made more spatial and temporal errors than controls. Females with 22q11.2DS made more spatial and temporal errors than males. These results extend findings of impaired spatiotemporal processing into the memory domain in 22q11.2DS by documenting their influence on working memory performance.

Original languageEnglish (US)
Pages (from-to)115-132
Number of pages18
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume119
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • 22q11.2DS
  • Proactive interference
  • Spatial working memory
  • Visuospatial attention

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Fingerprint Dive into the research topics of 'Children with chromosome 22q11.2 deletion syndrome exhibit impaired spatial working memory'. Together they form a unique fingerprint.

  • Cite this