Children hospitalized for varicella: A prevaccine review

C. L. Peterson, L. Mascola, S. M. Chao, J. M. Lieberman, E. L. Arcinue, Dean A Blumberg, Sik Kim Kwang Sik Kim, A. Kovacs, V. K. Wong, P. A. Brunell

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Objectives: To describe varicella complications in healthy and previously ill children hospitalized for varicella and to explore trends in group A β-hemolytic streptococcus complications of varicella. Methods: A retrospective record review of children hospitalized for varicella between January 1, 1990, and March 31, 1994, was conducted in nine large acute care hospitals in Los Angeles County, California. Results: We identified 574 children hospitalized for varicella in study hospitals during the 4.25-year study period (estimated risk of hospitalization, approximately 1 in 550 cases of varicella); 53% of the children were healthy before the onset of varicella and 47% were previously ill with underlying cancers or other chronic illnesses. Children were hospitalized for treatment of complications (n = 427, 74%) or for prophylactic antiviral therapy or observation (n = 147, 26%). Systems involved in complications included skin/soft tissue (45%), neurologic (18%), respiratory (14%), gastrointestinal (10%), and hematologic, renal, or hepatic (8% or less). The mean age of children with skin/soft tissue infections was 2.7 years (range < 1 to 16 years) compared with 4.7 years (< 1 to 18 years) for other complications. Children with skin/soft tissue and neurologic complications were more often previously healthy (p <0.05), whereas those with respiratory complications were more often previously ill (p <0.001). Hospitalizations for skin/soft tissue infections increased during the study period. The proportion of complications as a result of group A β-hemolytic streptococcus infection increased from 4.7% before 1993 to 12.2% for the remainder of the study period (p = 0.02). Conclusions: Prior health status was predictive of the type of complications experienced by children with varicella requiring hospitalization. Our data suggest a recent increase in skin/soft tissue complications of varicella requiring hospitalization and an increase in the proportion of complications related to group A β-hemolytic streptococcus. Wide-scale vaccine use should reverse this trend and reduce the overall impact of varicella on both healthy and previously ill children.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalJournal of Pediatrics
Issue number4
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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