Childhood Socioeconomic Status and Menarche: A Prospective Study

Robert A. Hiatt, Susan L. Stewart, Julianna Deardorff, Elizabeth Danial, Ekland Abdiwahab, Susan M. Pinney, Susan L. Teitelbaum, Gayle C. Windham, Mary S. Wolff, Lawrence Kushi, Frank M. Biro

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: The relationship between socioeconomic status (SES) and menarche has implications for understanding social level influences on early life development and adult disease, including breast cancer, but remains ill defined. We report here results from the Breast Cancer and the Environment Research Program, which permitted a longitudinal study of age at menarche in relationship to childhood SES in a diverse cohort of 1,069 girls across three urban areas of the United States. Methods: We assessed the association of SES index quintiles with age at pubertal onset with breast budding and subsequent tempo to the age at menarche between 2004 and 2015 using multiple-event Cox regression models to estimate hazard ratios and 95% confidence intervals. Results: In an unadjusted model, lower SES was predictive of both earlier pubertal onset and tempo and thus earlier age at menarche in trends across quintiles. After adjusting for the potentially mediating effects of body mass index, SES trends remained significant for both outcomes. After adjusting for both body mass index and race/ethnicity, the association with SES remained substantial for pubertal onset but was much diminished and nonsignificant for tempo and thus age at menarche. Conclusions: These results suggest that a lower SES environment and social adversity affect the age at menarche primarily by hastening pubertal onset rather than by shortening tempo.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalJournal of Adolescent Health
Volume69
Issue number1
DOIs
StatePublished - Jul 2021

Keywords

  • Breast cancer
  • cohort
  • obesity
  • puberty
  • race/ethnicity
  • socioeconomic status

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

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