Childbearing may increase visceral adipose tissue independent of overall increase in body fat

Erica P. Gunderson, Barbara Sternfeld, Melissa F. Wellons, Rachel Whitmer, Vicky Chiang, Charles P. Quesenberry Jr, Cora E. Lewis, Stephen Sidney

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: To examine whether childbearing is associated with increased visceral adiposity and whether the increase is proportionally larger than other depots. Methods and Procedures: This prospective study examined changes in adiposity assessed via computed tomography (CT) and dual-energy X-ray absorptiometry among 122 premenopausal women (50 black, 72 white) examined in 1995-1996 and again in 2000-2001. During the 5-year interval, 14 women had one interim birth and 108 had no interim births. Multiple linear regression models estimated mean (95% confidence interval (CI)) 5-year changes in anthropometric and adiposity measures by interim births adjusted for age, race, and changes in total and subcutaneous adiposity. Results: We found no significant differences between one interim birth and no interim births for 5-year changes in weight, BMI, total body fat, subcutaneous adipose tissue, or total abdominal adipose tissue. Visceral adipose tissue increased by 40 and 14% above initial levels for 1 birth and 0 birth groups, respectively. Having 1 birth vs. 0 births was associated with a greater increase in visceral adipose tissue of 18.0 cm 2 (4.8, 31.2), P < 0.01; gain of 27.1 cm2 (14.5, 39.7) vs. 9.2 cm2 (4.8, 13.6), and a borderline greater increase in waist girth of 2.3 cm (0, 4.5), P = 0.05; gain of 6.3 cm (4.1, 8.5) vs. 4.0 cm (3.2, 4.8), controlling for gain in total body fat and covariates. Discussion: Pregnancy may be associated with preferential accumulation of adipose tissue in the visceral compartment for similar gains in total body fat. Further investigation is needed to confirm these findings and determine whether excess visceral fat deposition with pregnancy adversely affects metabolic risk profiles among women.

Original languageEnglish (US)
Pages (from-to)1078-1084
Number of pages7
JournalObesity
Volume16
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Intra-Abdominal Fat
Adipose Tissue
Parturition
Adiposity
Linear Models
Pregnancy
Abdominal Fat
Metabolome
Subcutaneous Fat
Photon Absorptiometry
Tomography
Prospective Studies
Confidence Intervals
Weights and Measures

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Gunderson, E. P., Sternfeld, B., Wellons, M. F., Whitmer, R., Chiang, V., Quesenberry Jr, C. P., ... Sidney, S. (2008). Childbearing may increase visceral adipose tissue independent of overall increase in body fat. Obesity, 16(5), 1078-1084. https://doi.org/10.1038/oby.2008.40

Childbearing may increase visceral adipose tissue independent of overall increase in body fat. / Gunderson, Erica P.; Sternfeld, Barbara; Wellons, Melissa F.; Whitmer, Rachel; Chiang, Vicky; Quesenberry Jr, Charles P.; Lewis, Cora E.; Sidney, Stephen.

In: Obesity, Vol. 16, No. 5, 01.05.2008, p. 1078-1084.

Research output: Contribution to journalArticle

Gunderson, EP, Sternfeld, B, Wellons, MF, Whitmer, R, Chiang, V, Quesenberry Jr, CP, Lewis, CE & Sidney, S 2008, 'Childbearing may increase visceral adipose tissue independent of overall increase in body fat', Obesity, vol. 16, no. 5, pp. 1078-1084. https://doi.org/10.1038/oby.2008.40
Gunderson EP, Sternfeld B, Wellons MF, Whitmer R, Chiang V, Quesenberry Jr CP et al. Childbearing may increase visceral adipose tissue independent of overall increase in body fat. Obesity. 2008 May 1;16(5):1078-1084. https://doi.org/10.1038/oby.2008.40
Gunderson, Erica P. ; Sternfeld, Barbara ; Wellons, Melissa F. ; Whitmer, Rachel ; Chiang, Vicky ; Quesenberry Jr, Charles P. ; Lewis, Cora E. ; Sidney, Stephen. / Childbearing may increase visceral adipose tissue independent of overall increase in body fat. In: Obesity. 2008 ; Vol. 16, No. 5. pp. 1078-1084.
@article{6d3f0e9366ce43de8fa1b743a1d0c8a1,
title = "Childbearing may increase visceral adipose tissue independent of overall increase in body fat",
abstract = "Objective: To examine whether childbearing is associated with increased visceral adiposity and whether the increase is proportionally larger than other depots. Methods and Procedures: This prospective study examined changes in adiposity assessed via computed tomography (CT) and dual-energy X-ray absorptiometry among 122 premenopausal women (50 black, 72 white) examined in 1995-1996 and again in 2000-2001. During the 5-year interval, 14 women had one interim birth and 108 had no interim births. Multiple linear regression models estimated mean (95{\%} confidence interval (CI)) 5-year changes in anthropometric and adiposity measures by interim births adjusted for age, race, and changes in total and subcutaneous adiposity. Results: We found no significant differences between one interim birth and no interim births for 5-year changes in weight, BMI, total body fat, subcutaneous adipose tissue, or total abdominal adipose tissue. Visceral adipose tissue increased by 40 and 14{\%} above initial levels for 1 birth and 0 birth groups, respectively. Having 1 birth vs. 0 births was associated with a greater increase in visceral adipose tissue of 18.0 cm 2 (4.8, 31.2), P < 0.01; gain of 27.1 cm2 (14.5, 39.7) vs. 9.2 cm2 (4.8, 13.6), and a borderline greater increase in waist girth of 2.3 cm (0, 4.5), P = 0.05; gain of 6.3 cm (4.1, 8.5) vs. 4.0 cm (3.2, 4.8), controlling for gain in total body fat and covariates. Discussion: Pregnancy may be associated with preferential accumulation of adipose tissue in the visceral compartment for similar gains in total body fat. Further investigation is needed to confirm these findings and determine whether excess visceral fat deposition with pregnancy adversely affects metabolic risk profiles among women.",
author = "Gunderson, {Erica P.} and Barbara Sternfeld and Wellons, {Melissa F.} and Rachel Whitmer and Vicky Chiang and {Quesenberry Jr}, {Charles P.} and Lewis, {Cora E.} and Stephen Sidney",
year = "2008",
month = "5",
day = "1",
doi = "10.1038/oby.2008.40",
language = "English (US)",
volume = "16",
pages = "1078--1084",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Childbearing may increase visceral adipose tissue independent of overall increase in body fat

AU - Gunderson, Erica P.

AU - Sternfeld, Barbara

AU - Wellons, Melissa F.

AU - Whitmer, Rachel

AU - Chiang, Vicky

AU - Quesenberry Jr, Charles P.

AU - Lewis, Cora E.

AU - Sidney, Stephen

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Objective: To examine whether childbearing is associated with increased visceral adiposity and whether the increase is proportionally larger than other depots. Methods and Procedures: This prospective study examined changes in adiposity assessed via computed tomography (CT) and dual-energy X-ray absorptiometry among 122 premenopausal women (50 black, 72 white) examined in 1995-1996 and again in 2000-2001. During the 5-year interval, 14 women had one interim birth and 108 had no interim births. Multiple linear regression models estimated mean (95% confidence interval (CI)) 5-year changes in anthropometric and adiposity measures by interim births adjusted for age, race, and changes in total and subcutaneous adiposity. Results: We found no significant differences between one interim birth and no interim births for 5-year changes in weight, BMI, total body fat, subcutaneous adipose tissue, or total abdominal adipose tissue. Visceral adipose tissue increased by 40 and 14% above initial levels for 1 birth and 0 birth groups, respectively. Having 1 birth vs. 0 births was associated with a greater increase in visceral adipose tissue of 18.0 cm 2 (4.8, 31.2), P < 0.01; gain of 27.1 cm2 (14.5, 39.7) vs. 9.2 cm2 (4.8, 13.6), and a borderline greater increase in waist girth of 2.3 cm (0, 4.5), P = 0.05; gain of 6.3 cm (4.1, 8.5) vs. 4.0 cm (3.2, 4.8), controlling for gain in total body fat and covariates. Discussion: Pregnancy may be associated with preferential accumulation of adipose tissue in the visceral compartment for similar gains in total body fat. Further investigation is needed to confirm these findings and determine whether excess visceral fat deposition with pregnancy adversely affects metabolic risk profiles among women.

AB - Objective: To examine whether childbearing is associated with increased visceral adiposity and whether the increase is proportionally larger than other depots. Methods and Procedures: This prospective study examined changes in adiposity assessed via computed tomography (CT) and dual-energy X-ray absorptiometry among 122 premenopausal women (50 black, 72 white) examined in 1995-1996 and again in 2000-2001. During the 5-year interval, 14 women had one interim birth and 108 had no interim births. Multiple linear regression models estimated mean (95% confidence interval (CI)) 5-year changes in anthropometric and adiposity measures by interim births adjusted for age, race, and changes in total and subcutaneous adiposity. Results: We found no significant differences between one interim birth and no interim births for 5-year changes in weight, BMI, total body fat, subcutaneous adipose tissue, or total abdominal adipose tissue. Visceral adipose tissue increased by 40 and 14% above initial levels for 1 birth and 0 birth groups, respectively. Having 1 birth vs. 0 births was associated with a greater increase in visceral adipose tissue of 18.0 cm 2 (4.8, 31.2), P < 0.01; gain of 27.1 cm2 (14.5, 39.7) vs. 9.2 cm2 (4.8, 13.6), and a borderline greater increase in waist girth of 2.3 cm (0, 4.5), P = 0.05; gain of 6.3 cm (4.1, 8.5) vs. 4.0 cm (3.2, 4.8), controlling for gain in total body fat and covariates. Discussion: Pregnancy may be associated with preferential accumulation of adipose tissue in the visceral compartment for similar gains in total body fat. Further investigation is needed to confirm these findings and determine whether excess visceral fat deposition with pregnancy adversely affects metabolic risk profiles among women.

UR - http://www.scopus.com/inward/record.url?scp=42949150861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949150861&partnerID=8YFLogxK

U2 - 10.1038/oby.2008.40

DO - 10.1038/oby.2008.40

M3 - Article

C2 - 18356843

AN - SCOPUS:42949150861

VL - 16

SP - 1078

EP - 1084

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -