Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective

Jemianne Bautista Jia; Chandana Lall; Temel Tirkes; Rajesh Gulati; Ramit Lamba; Scott C. Goodwin

doi:10.1007/s13244-015-0417-x

Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective

Jemianne Bautista Jia, Chandana Lall, Temel Tirkes, Rajesh Gulati, Ramit Lamba, Scott C. Goodwin

Radiology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Abstract: Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians. Teaching Points: • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.

Original language	English (US)
Pages (from-to)	479-487
Number of pages	9
Journal	Insights into Imaging
Volume	6
Issue number	4
DOIs	https://doi.org/10.1007/s13244-015-0417-x
State	Published - Aug 29 2015

Keywords

Biologic agents
Chemotherapy
Drug-associated adverse effects
Nephrotoxicity
Renal cysts

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective",

abstract = "Abstract: Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians. Teaching Points: • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.",

keywords = "Biologic agents, Chemotherapy, Drug-associated adverse effects, Nephrotoxicity, Renal cysts",

author = "Jia, {Jemianne Bautista} and Chandana Lall and Temel Tirkes and Rajesh Gulati and Ramit Lamba and Goodwin, {Scott C.}",

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T1 - Chemotherapy-related complications in the kidneys and collecting system

T2 - an imaging perspective

AU - Jia, Jemianne Bautista

AU - Lall, Chandana

AU - Tirkes, Temel

AU - Gulati, Rajesh

AU - Lamba, Ramit

AU - Goodwin, Scott C.

PY - 2015/8/29

Y1 - 2015/8/29

N2 - Abstract: Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians. Teaching Points: • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.

AB - Abstract: Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians. Teaching Points: • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.

KW - Biologic agents

KW - Chemotherapy

KW - Drug-associated adverse effects

KW - Nephrotoxicity

KW - Renal cysts

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