The desirability of an animal model of human prostatic adenocarcinoma is based on major theoretical and practical considerations. The Nb rat prostatic adenocarcinoma is induced by implantation of hormones, testosterone, and estrogen in young rats and mimics the human condition with respect to hormone dependence, histology, and obstruction of the urinary tract. These Nb rat prostatic adenocarcinomas have been heterotransplanted into athymic (nude) mice and provide a useful model to evaluate chemotherapy. Herein is reported preliminary experience with the use of cyclosphosphamide, adriamycin, and 5-fluorouracil on these tumors.
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