TY - JOUR
T1 - Chemotherapy of advanced renal adenocarcinoma
AU - Cockburn, Alden G.
AU - deVere White, Ralph W
PY - 1984/7
Y1 - 1984/7
N2 - The treatment of advanced renal cell carcinoma is a continuing problem because of the lack of effective systenic therapy. A review of recent clinical trials of various chemotherapeutic agents reveals vinblastine, CCNU, and Methyl GAG to be the most effective of all agents tested. This efficacy however, is in the modest range of 15% partial response. Somewhat increased efficacy is seen in combination regimens containing vinblastine. Hormonal therapy with progestins and androgens is widely used because of their slight efficacy, lack of toxicity, and the psychological benefit of doing something. It should be considered, when judging the efficacy of any systemic therapy used in this disease, that the patients with minimal pulmonary disease always fair the best.
AB - The treatment of advanced renal cell carcinoma is a continuing problem because of the lack of effective systenic therapy. A review of recent clinical trials of various chemotherapeutic agents reveals vinblastine, CCNU, and Methyl GAG to be the most effective of all agents tested. This efficacy however, is in the modest range of 15% partial response. Somewhat increased efficacy is seen in combination regimens containing vinblastine. Hormonal therapy with progestins and androgens is widely used because of their slight efficacy, lack of toxicity, and the psychological benefit of doing something. It should be considered, when judging the efficacy of any systemic therapy used in this disease, that the patients with minimal pulmonary disease always fair the best.
UR - http://www.scopus.com/inward/record.url?scp=0021637359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021637359&partnerID=8YFLogxK
U2 - 10.1007/BF00328094
DO - 10.1007/BF00328094
M3 - Article
AN - SCOPUS:0021637359
VL - 2
SP - 136
EP - 141
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 2
ER -