The Nb rat prostatic adenocarcinoma model has been evaluated utilizing the autonomous tumor Nb Pr A.I.-1. Chemotherapeutic evaluation as well as radiation treatment of tumors was employed. Chemotherapy was evaluated in Nb rats as well as congenitally athymic (nude) mice. Adriamycin, cyclophosphamide, and N,N-bis(2-chloroethyl)-N-nitrosourea were all significant (P < 0.01); however, the methotrexate-treated animals as well as animals receiving the low dose of adriamycin were not affected by these modalities. Similar results were observed in both Nb rats as well as nude mice in respect to the affect of chemotherapy. Also, this model has been used to evaluate the affect of irradiating the 2-mm3 wedges of tumor tissue with the following doses of radiation: 250, 500, 1000, and 1500 rad. Tumor growth retardation was observed in animals receiving greater than 1000 rad.
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