Abstract
The Nb rat prostatic adenocarcinoma model has been evaluated utilizing the autonomous tumor Nb Pr A.I.-1. Chemotherapeutic evaluation as well as radiation treatment of tumors was employed. Chemotherapy was evaluated in Nb rats as well as congenitally athymic (nude) mice. Adriamycin, cyclophosphamide, and N,N-bis(2-chloroethyl)-N-nitrosourea were all significant (P < 0.01); however, the methotrexate-treated animals as well as animals receiving the low dose of adriamycin were not affected by these modalities. Similar results were observed in both Nb rats as well as nude mice in respect to the affect of chemotherapy. Also, this model has been used to evaluate the affect of irradiating the 2-mm3 wedges of tumor tissue with the following doses of radiation: 250, 500, 1000, and 1500 rad. Tumor growth retardation was observed in animals receiving greater than 1000 rad.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 492-496 |
| Number of pages | 5 |
| Journal | Journal of Surgical Research |
| Volume | 28 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Surgery
Cite this
Chemotherapy and radiation of Nb rat prostatic adenocarcinoma : Nb Pr-A.I.-1. / Drago, Joseph R.; Goldman, Lawrence; Gershwin, M. Eric.
In: Journal of Surgical Research, Vol. 28, No. 6, 1980, p. 492-496.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemotherapy and radiation of Nb rat prostatic adenocarcinoma
T2 - Nb Pr-A.I.-1
AU - Drago, Joseph R.
AU - Goldman, Lawrence
AU - Gershwin, M. Eric
PY - 1980
Y1 - 1980
N2 - The Nb rat prostatic adenocarcinoma model has been evaluated utilizing the autonomous tumor Nb Pr A.I.-1. Chemotherapeutic evaluation as well as radiation treatment of tumors was employed. Chemotherapy was evaluated in Nb rats as well as congenitally athymic (nude) mice. Adriamycin, cyclophosphamide, and N,N-bis(2-chloroethyl)-N-nitrosourea were all significant (P < 0.01); however, the methotrexate-treated animals as well as animals receiving the low dose of adriamycin were not affected by these modalities. Similar results were observed in both Nb rats as well as nude mice in respect to the affect of chemotherapy. Also, this model has been used to evaluate the affect of irradiating the 2-mm3 wedges of tumor tissue with the following doses of radiation: 250, 500, 1000, and 1500 rad. Tumor growth retardation was observed in animals receiving greater than 1000 rad.
AB - The Nb rat prostatic adenocarcinoma model has been evaluated utilizing the autonomous tumor Nb Pr A.I.-1. Chemotherapeutic evaluation as well as radiation treatment of tumors was employed. Chemotherapy was evaluated in Nb rats as well as congenitally athymic (nude) mice. Adriamycin, cyclophosphamide, and N,N-bis(2-chloroethyl)-N-nitrosourea were all significant (P < 0.01); however, the methotrexate-treated animals as well as animals receiving the low dose of adriamycin were not affected by these modalities. Similar results were observed in both Nb rats as well as nude mice in respect to the affect of chemotherapy. Also, this model has been used to evaluate the affect of irradiating the 2-mm3 wedges of tumor tissue with the following doses of radiation: 250, 500, 1000, and 1500 rad. Tumor growth retardation was observed in animals receiving greater than 1000 rad.
UR - http://www.scopus.com/inward/record.url?scp=0018889694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018889694&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(80)90040-2
DO - 10.1016/0022-4804(80)90040-2
M3 - Article
C2 - 7421169
AN - SCOPUS:0018889694
VL - 28
SP - 492
EP - 496
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 6
ER -