Chemotaxis of rat retinal glia to growth factors found in repairing wounds

A. K. Harvey, F. Roberge, Leonard M Hjelmeland

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Retinal glia migrate to sites in the vitreous body and on the inner and outer surfaces of the retina during a wide variety of pathological processes. Using in vitro cultures of rat retinal glia, we have evaluated an extensive list of homogeneous, well-characterized growth factors as chemoattractants for these cells. Humoral growth factors, fibroblast growth factors, extracellular matrix proteins and immune system cytokines all were without activity except for the platelet-derived growth factor (PDGF). Extracts of bovine ocular tissues including vitreous body and retina yielded significant activity.

Original languageEnglish (US)
Pages (from-to)1092-1099
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume28
Issue number7
StatePublished - 1987

ASJC Scopus subject areas

  • Ophthalmology

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