Chemotaxis of rat brain astrocytes to platelet derived growth factor

J. P. Bressler; G. R. Grotendorst; C. Levitov; Leonard M Hjelmeland

doi:10.1016/0006-8993(85)90802-9

Chemotaxis of rat brain astrocytes to platelet derived growth factor

J. P. Bressler, G. R. Grotendorst, C. Levitov, Leonard M Hjelmeland

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Using a purified population of rat brain astrocytes prepared from neonatal cortex, we investigated the chemotaxis of astroglia to several well characterized growth factors. Chemotactic activity for astrocytes was found for the platelet derived growth factor with a half maximal response occurring at 0.5 ng/ml as compared with a value of 2-3 ng/ml obtained for NIH/3T3 fibroblasts in control experiments. Other growth factors including epidermal growth factor, fibroblast growth factor and insulin were inactive as chemoattractants. Affinity purified fibronectin was also found to stimulate the migration of astroglia, with half maximal doses of approximately 1 μg/ml relative to maximal responses to platelet derived growth factor.

Original language	English (US)
Pages (from-to)	249-254
Number of pages	6
Journal	Brain Research
Volume	344
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(85)90802-9
State	Published - Oct 7 1985
Externally published	Yes

Keywords

astrocyte
chemotaxis
fibronectin
platelet derived growth factor
wound repair

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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AU - Grotendorst, G. R.

AU - Levitov, C.

AU - Hjelmeland, Leonard M

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KW - fibronectin

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KW - wound repair

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Chemotaxis of rat brain astrocytes to platelet derived growth factor

Abstract

Keywords

ASJC Scopus subject areas

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