Chemosensitivity of murine renal carcinoma

Ralph W deVere White; W. Ki Hong; T. Tannenbaum; C. A. Olsson

doi:10.1007/BF00256520

Chemosensitivity of murine renal carcinoma

Ralph W deVere White, W. Ki Hong, T. Tannenbaum, C. A. Olsson

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A non-endocrine dependent, spontaneous carcinoma of the kidney in a Wistar-Lewis rat has been studied for sensitivity to chemotherapeutic agents. Two tumour models have been employed. Subcutaneously transplanted flank nodules were used to screen single agents for antitumour activity. A model of intraperitoneal metastatic disease was employed to test further agents which had demonstrated some effectiveness in the nodule model. Single agents that proved ineffective were streptozotocin, neocarzinostatin, chlorozotocin and carminomycin. 5-FU, bleomycin and hydroxyurea were also ineffective at the doses tested. Agents that were effective included cyclophosphamide, adriamycin, vinblastine, vindesin, and maytansine. The most effective combination therapy appeared to be cyclophosphamide with vindesin and cisplatin.

Original language	English (US)
Pages (from-to)	27-30
Number of pages	4
Journal	Urological Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/BF00256520
State	Published - Feb 1982
Externally published	Yes

Keywords

Animal model
Chemosensitivity
Renal carcinoma

ASJC Scopus subject areas

Urology

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10.1007/BF00256520

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AU - Ki Hong, W.

AU - Tannenbaum, T.

AU - Olsson, C. A.

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AB - A non-endocrine dependent, spontaneous carcinoma of the kidney in a Wistar-Lewis rat has been studied for sensitivity to chemotherapeutic agents. Two tumour models have been employed. Subcutaneously transplanted flank nodules were used to screen single agents for antitumour activity. A model of intraperitoneal metastatic disease was employed to test further agents which had demonstrated some effectiveness in the nodule model. Single agents that proved ineffective were streptozotocin, neocarzinostatin, chlorozotocin and carminomycin. 5-FU, bleomycin and hydroxyurea were also ineffective at the doses tested. Agents that were effective included cyclophosphamide, adriamycin, vinblastine, vindesin, and maytansine. The most effective combination therapy appeared to be cyclophosphamide with vindesin and cisplatin.

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Chemosensitivity of murine renal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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