Chemoradiation for primary invasive squamous carcinoma of the vagina

John L. Dalrymple, A. H. Russell, S. W. Lee, Sidney A Scudder, Gary S Leiserowitz, W. K. Kinney, Lloyd H Smith

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Objective: To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation. Methods: Between 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient). Results: One patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74-168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae. Conclusions: Radiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalInternational Journal of Gynecological Cancer
Volume14
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Vagina
Squamous Cell Carcinoma
Radiation
Drug Therapy
Neoplasms
Brachytherapy
Mitomycin
Fluorouracil
Cisplatin
Fistula
Therapeutics

Keywords

  • Brachytherapy
  • Chemotherapy
  • Radiation therapy
  • Vaginal neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology
  • Cancer Research

Cite this

Chemoradiation for primary invasive squamous carcinoma of the vagina. / Dalrymple, John L.; Russell, A. H.; Lee, S. W.; Scudder, Sidney A; Leiserowitz, Gary S; Kinney, W. K.; Smith, Lloyd H.

In: International Journal of Gynecological Cancer, Vol. 14, No. 1, 01.2004, p. 110-117.

Research output: Contribution to journalArticle

@article{27f6ff5c13794368ab5a872b9364c541,
title = "Chemoradiation for primary invasive squamous carcinoma of the vagina",
abstract = "Objective: To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation. Methods: Between 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient). Results: One patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74-168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae. Conclusions: Radiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.",
keywords = "Brachytherapy, Chemotherapy, Radiation therapy, Vaginal neoplasms",
author = "Dalrymple, {John L.} and Russell, {A. H.} and Lee, {S. W.} and Scudder, {Sidney A} and Leiserowitz, {Gary S} and Kinney, {W. K.} and Smith, {Lloyd H}",
year = "2004",
month = "1",
doi = "10.1111/j.1048-891x.2004.014066.x",
language = "English (US)",
volume = "14",
pages = "110--117",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Chemoradiation for primary invasive squamous carcinoma of the vagina

AU - Dalrymple, John L.

AU - Russell, A. H.

AU - Lee, S. W.

AU - Scudder, Sidney A

AU - Leiserowitz, Gary S

AU - Kinney, W. K.

AU - Smith, Lloyd H

PY - 2004/1

Y1 - 2004/1

N2 - Objective: To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation. Methods: Between 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient). Results: One patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74-168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae. Conclusions: Radiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.

AB - Objective: To report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation. Methods: Between 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient). Results: One patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74-168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae. Conclusions: Radiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.

KW - Brachytherapy

KW - Chemotherapy

KW - Radiation therapy

KW - Vaginal neoplasms

UR - http://www.scopus.com/inward/record.url?scp=1442348469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1442348469&partnerID=8YFLogxK

U2 - 10.1111/j.1048-891x.2004.014066.x

DO - 10.1111/j.1048-891x.2004.014066.x

M3 - Article

C2 - 14764038

AN - SCOPUS:1442348469

VL - 14

SP - 110

EP - 117

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 1

ER -