Chemokines, chemokine receptors, and cancer metastasis

Takashi Kakinuma, Samuel T Hwang

Research output: Contribution to journalReview article

242 Citations (Scopus)

Abstract

It is clear from large clinical studies that selected chemokine receptors are often upregulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant roles in cancer metastasis to vital organs as well as regional lymph nodes, the most frequent site of cancer metastasis. Chemokine receptors may potentially facilitate tumor dissemination at several key steps of metastasis, including adherence of tumor cells to endothelium, extravasation from blood vessels, metastatic colonization, angiogenesis, proliferation, and protection from the host response via activation of key survival pathways such as phosphatidylinositol-3 kinase and Akt. It is interesting that many of these roles are reminiscent of their functions in leukocyte and stem cell trafficking. Lastly, we discuss therapeutic applications for chemokine receptor antagonists in cancer therapy.

Original languageEnglish (US)
Pages (from-to)639-651
Number of pages13
JournalJournal of Leukocyte Biology
Volume79
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Chemokine Receptors
Chemokines
Neoplasm Metastasis
Neoplasms
Phosphatidylinositol 3-Kinase
Endothelium
Blood Vessels
Prostate
Melanoma
Colon
Breast
Leukocytes
Stem Cells
Lymph Nodes
Ligands
Lung
Survival
Therapeutics

Keywords

  • Akt
  • Carcinoma
  • Melanoma
  • PI-3K

ASJC Scopus subject areas

  • Cell Biology

Cite this

Chemokines, chemokine receptors, and cancer metastasis. / Kakinuma, Takashi; Hwang, Samuel T.

In: Journal of Leukocyte Biology, Vol. 79, No. 4, 04.2006, p. 639-651.

Research output: Contribution to journalReview article

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