Abstract
It is clear from large clinical studies that selected chemokine receptors are often upregulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant roles in cancer metastasis to vital organs as well as regional lymph nodes, the most frequent site of cancer metastasis. Chemokine receptors may potentially facilitate tumor dissemination at several key steps of metastasis, including adherence of tumor cells to endothelium, extravasation from blood vessels, metastatic colonization, angiogenesis, proliferation, and protection from the host response via activation of key survival pathways such as phosphatidylinositol-3 kinase and Akt. It is interesting that many of these roles are reminiscent of their functions in leukocyte and stem cell trafficking. Lastly, we discuss therapeutic applications for chemokine receptor antagonists in cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 639-651 |
| Number of pages | 13 |
| Journal | Journal of Leukocyte Biology |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2006 |
| Externally published | Yes |
Fingerprint
Keywords
- Akt
- Carcinoma
- Melanoma
- PI-3K
ASJC Scopus subject areas
- Cell Biology
Cite this
Chemokines, chemokine receptors, and cancer metastasis. / Kakinuma, Takashi; Hwang, Samuel T.
In: Journal of Leukocyte Biology, Vol. 79, No. 4, 04.2006, p. 639-651.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chemokines, chemokine receptors, and cancer metastasis
AU - Kakinuma, Takashi
AU - Hwang, Samuel T
PY - 2006/4
Y1 - 2006/4
N2 - It is clear from large clinical studies that selected chemokine receptors are often upregulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant roles in cancer metastasis to vital organs as well as regional lymph nodes, the most frequent site of cancer metastasis. Chemokine receptors may potentially facilitate tumor dissemination at several key steps of metastasis, including adherence of tumor cells to endothelium, extravasation from blood vessels, metastatic colonization, angiogenesis, proliferation, and protection from the host response via activation of key survival pathways such as phosphatidylinositol-3 kinase and Akt. It is interesting that many of these roles are reminiscent of their functions in leukocyte and stem cell trafficking. Lastly, we discuss therapeutic applications for chemokine receptor antagonists in cancer therapy.
AB - It is clear from large clinical studies that selected chemokine receptors are often upregulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant roles in cancer metastasis to vital organs as well as regional lymph nodes, the most frequent site of cancer metastasis. Chemokine receptors may potentially facilitate tumor dissemination at several key steps of metastasis, including adherence of tumor cells to endothelium, extravasation from blood vessels, metastatic colonization, angiogenesis, proliferation, and protection from the host response via activation of key survival pathways such as phosphatidylinositol-3 kinase and Akt. It is interesting that many of these roles are reminiscent of their functions in leukocyte and stem cell trafficking. Lastly, we discuss therapeutic applications for chemokine receptor antagonists in cancer therapy.
KW - Akt
KW - Carcinoma
KW - Melanoma
KW - PI-3K
UR - http://www.scopus.com/inward/record.url?scp=33746051169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746051169&partnerID=8YFLogxK
U2 - 10.1189/jlb.1105633
DO - 10.1189/jlb.1105633
M3 - Review article
C2 - 16478915
AN - SCOPUS:33746051169
VL - 79
SP - 639
EP - 651
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 4
ER -