Chemokines

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chemokines are a unique class of chemoattractant proteins that, in conjunction with their G protein-coupled receptors, are crucial for orienting cell migration. Chemokines control developmental processes and, in pathological conditions, modulate inflammation and other host responses by controlling migration of immune cells. Furthermore, chemokines play decisive roles in tumor biology by promoting angiogenesis, metastasis, and cell proliferation. Here, the authors discuss how chemokines affect the nervous system under physiological conditions and in neurological disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages764-769
Number of pages6
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Keywords

  • Alzheimer's disease
  • Cell trafficking
  • Central nervous system
  • Chemokine receptors
  • Chemokines
  • CNS tumors
  • Degenerative neurological disorders
  • G protein-coupled receptors
  • HIV
  • Huntington's disease
  • Inflammatory neurological disorders
  • Multiple sclerosis
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Soulika, A., & Pleasure, D. E. (2014). Chemokines. In Encyclopedia of the Neurological Sciences (pp. 764-769). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00174-3