Chemokine receptors in the pathogenesis and therapy of psoriasis

Tomotaka Mabuchi, Timothy W. Chang, Suzanne Quinter, Samuel T Hwang

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Chemokine receptors are G-protein-coupled, seven-transmembrane-spanning surface receptors that play key roles in cell trafficking, cell motility, and survival. These receptors are activated by small molecular weight chemotactic cytokines called chemokines. Chemokine receptors and their corresponding chemokine ligands play roles in the migration and localization of normal T cells (and other cells) during physiological responses in inflamed or infected skin. In psoriasis, the chemokine receptor CCR6 is expressed on the Th17 cells and γδ T cells, which produce a variety of cytokines (IL17 and IL22 among others), that play a role in the immunological activation. CCR6 and its ligand, CCL20, are highly expressed in psoriatic skin lesion and CCR6 is essential for the development of the psoriasiform phenotype following IL23 injection in mouse skin. In this review, we focus on the roles of chemokine receptors, particularly of CCR6, in the pathogenesis of psoriasis and discuss chemokine receptors as novel therapeutic targets for psoriasis.

Original languageEnglish (US)
Pages (from-to)4-11
Number of pages8
JournalJournal of Dermatological Science
Volume65
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • γδ T cells
  • CCR6
  • Chemokine receptors
  • IL22
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Chemokine receptors in the pathogenesis and therapy of psoriasis'. Together they form a unique fingerprint.

  • Cite this