Abstract
The chemokine/chemokine receptor network is an integral element of the complex system of homeostasis and immunosurveillance. Initially studied because of their role in coordinating tissue-specific migration and activation of leucocytes, chemokines have been implicated in the pathogenesis of various malignancies and diseases with strong inflammatory components. We discuss recent findings suggesting a critical involvement of chemokine receptor interactions in the immunopathogenesis of classical inflammatory skin disorders such as psoriasis and atopic dermatitis, as well as neoplastic diseases with a T-cell origin, such as mycosis fungoides. A deeper understanding of the underlying contribution of the chemokine network in the disease processes is key for the development of selective targeted immunotherapeutics that may meet the delicate balance between efficacy and safety.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2552-2566 |
| Number of pages | 15 |
| Journal | Journal of Investigative Dermatology |
| Volume | 129 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Chemokine receptors in T-Cell-mediated diseases of the skin. / Lonsdorf, Anke S.; Hwang, Samuel T; Enk, Alexander H.
In: Journal of Investigative Dermatology, Vol. 129, No. 11, 11.2009, p. 2552-2566.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chemokine receptors in T-Cell-mediated diseases of the skin
AU - Lonsdorf, Anke S.
AU - Hwang, Samuel T
AU - Enk, Alexander H.
PY - 2009/11
Y1 - 2009/11
N2 - The chemokine/chemokine receptor network is an integral element of the complex system of homeostasis and immunosurveillance. Initially studied because of their role in coordinating tissue-specific migration and activation of leucocytes, chemokines have been implicated in the pathogenesis of various malignancies and diseases with strong inflammatory components. We discuss recent findings suggesting a critical involvement of chemokine receptor interactions in the immunopathogenesis of classical inflammatory skin disorders such as psoriasis and atopic dermatitis, as well as neoplastic diseases with a T-cell origin, such as mycosis fungoides. A deeper understanding of the underlying contribution of the chemokine network in the disease processes is key for the development of selective targeted immunotherapeutics that may meet the delicate balance between efficacy and safety.
AB - The chemokine/chemokine receptor network is an integral element of the complex system of homeostasis and immunosurveillance. Initially studied because of their role in coordinating tissue-specific migration and activation of leucocytes, chemokines have been implicated in the pathogenesis of various malignancies and diseases with strong inflammatory components. We discuss recent findings suggesting a critical involvement of chemokine receptor interactions in the immunopathogenesis of classical inflammatory skin disorders such as psoriasis and atopic dermatitis, as well as neoplastic diseases with a T-cell origin, such as mycosis fungoides. A deeper understanding of the underlying contribution of the chemokine network in the disease processes is key for the development of selective targeted immunotherapeutics that may meet the delicate balance between efficacy and safety.
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UR - http://www.scopus.com/inward/citedby.url?scp=70350055354&partnerID=8YFLogxK
U2 - 10.1038/jid.2009.122
DO - 10.1038/jid.2009.122
M3 - Review article
C2 - 19474804
AN - SCOPUS:70350055354
VL - 129
SP - 2552
EP - 2566
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 11
ER -