Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide

Zhipeng Han, Congcong Chen, Caicai Meng, Tian Gao, Peng Peng, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.

Original languageEnglish (US)
Pages (from-to)412-422
Number of pages11
JournalJournal of Carbohydrate Chemistry
Volume35
Issue number8-9
DOIs
StatePublished - Nov 21 2016

Keywords

  • Chemoenzymatic synthesis
  • glycosyltransferase
  • human milk oligosaccharide
  • N3 minor antigen

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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