Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide

Zhipeng Han, Congcong Chen, Caicai Meng, Tian Gao, Peng Peng, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A highly efficient chemoenzymatic approach was developed for the preparative scale synthesis of complex tumor-associated antigen N3 minor octasaccharide. The success of this approach relies on the highly efficient one-pot multi-enzyme based sequential enzymatic elongation of a chemically synthesized branched tetrasaccharide core structure.

Original languageEnglish (US)
Pages (from-to)412-422
Number of pages11
JournalJournal of Carbohydrate Chemistry
Volume35
Issue number8-9
DOIs
StatePublished - Nov 21 2016

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Neoplasm Antigens
Tumors
Elongation
Antigens
Enzymes

Keywords

  • Chemoenzymatic synthesis
  • glycosyltransferase
  • human milk oligosaccharide
  • N3 minor antigen

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. / Han, Zhipeng; Chen, Congcong; Meng, Caicai; Gao, Tian; Peng, Peng; Chen, Xi; Wang, Fengshan; Cao, Hongzhi.

In: Journal of Carbohydrate Chemistry, Vol. 35, No. 8-9, 21.11.2016, p. 412-422.

Research output: Contribution to journalArticle

Han, Zhipeng ; Chen, Congcong ; Meng, Caicai ; Gao, Tian ; Peng, Peng ; Chen, Xi ; Wang, Fengshan ; Cao, Hongzhi. / Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. In: Journal of Carbohydrate Chemistry. 2016 ; Vol. 35, No. 8-9. pp. 412-422.
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