Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides

Saddam Muthana, Hai Yu, Shengshu Huang, Xi Chen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A novel chemoenzymatic method has been developed for the synthesis of size-defined polysaccharides with sialic acid-containing repeating units by sialyltransferase-catalyzed block transfer of oligosaccharides. The synthesized polysaccharides are mimics of surface polysaccharides produced by some pathogenic bacteria. Bacterial sialyltransferases, once again, have been confirmed to have flexible substrate specificity. They are extremely useful catalysts for efficient synthesis of diverse and complex sialic acid-containing carbohydrates and glycoconjugates.

Original languageEnglish (US)
Pages (from-to)11918-11919
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number39
DOIs
StatePublished - Oct 3 2007

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Sialyltransferases
Oligosaccharides
Polysaccharides
N-Acetylneuraminic Acid
Glycoconjugates
Acids
Carbohydrates
Substrate Specificity
Bacteria
Catalysts
Substrates

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides. / Muthana, Saddam; Yu, Hai; Huang, Shengshu; Chen, Xi.

In: Journal of the American Chemical Society, Vol. 129, No. 39, 03.10.2007, p. 11918-11919.

Research output: Contribution to journalArticle

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