Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives

Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Fluorinated Thomsen-Friedenreich (T) antigens were synthesized efficiently from chemically produced fluorinated monosaccharides using a highly efficient one-pot two-enzyme chemoenzymatic approach containing a galactokinase and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase. These fluorinated T-antigens were further sialylated to form fluorinated ST-antigens using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α-2-3-sialyltransferase. This journal is

Original languageEnglish (US)
Pages (from-to)842-848
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number5
DOIs
StatePublished - Feb 7 2013

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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