Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives

Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fluorinated Thomsen-Friedenreich (T) antigens were synthesized efficiently from chemically produced fluorinated monosaccharides using a highly efficient one-pot two-enzyme chemoenzymatic approach containing a galactokinase and a d-galactosyl-β1-3-N-acetyl-d-hexosamine phosphorylase. These fluorinated T-antigens were further sialylated to form fluorinated ST-antigens using a one-pot two-enzyme system containing a CMP-sialic acid synthetase and an α-2-3-sialyltransferase. This journal is

Original languageEnglish (US)
Pages (from-to)842-848
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number5
DOIs
StatePublished - Feb 7 2013

Fingerprint

Viral Tumor Antigens
antigens
N-Acylneuraminate Cytidylyltransferase
Galactokinase
Sialyltransferases
Derivatives
Hexosamines
Phosphorylases
Monosaccharides
enzymes
Enzymes
synthesis
monosaccharides
acids
Thomsen-Friedenreich antigen
sialosyl-T antigen

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives. / Yan, Jun; Chen, Xi; Wang, Fengshan; Cao, Hongzhi.

In: Organic and Biomolecular Chemistry, Vol. 11, No. 5, 07.02.2013, p. 842-848.

Research output: Contribution to journalArticle

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