Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao; Jun Yan; Xi Chen; Fengshan Wang; Hongzhi Cao

doi:10.1016/j.carres.2014.10.017

Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao, Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Chemistry

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

Original language	English (US)
Pages (from-to)	5-10
Number of pages	6
Journal	Carbohydrate Research
Volume	401
DOIs	https://doi.org/10.1016/j.carres.2014.10.017
State	Published - Jan 12 2015

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Keywords

Chemoenzymatic synthesis
Glycosylation
Lacto-N-tetrasaccharide
Sialyl lacto-N-tetrasaccharide
Sialylation

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Organic Chemistry

Cite this

Yao, W., Yan, J., Chen, X., Wang, F., & Cao, H. (2015). Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. Carbohydrate Research, 401, 5-10. https://doi.org/10.1016/j.carres.2014.10.017

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AU - Wang, Fengshan

AU - Cao, Hongzhi

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10.1016/j.carres.2014.10.017