Abstract
A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-10 |
| Number of pages | 6 |
| Journal | Carbohydrate Research |
| Volume | 401 |
| DOIs | |
| State | Published - Jan 12 2015 |
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Keywords
- Chemoenzymatic synthesis
- Glycosylation
- Lacto-N-tetrasaccharide
- Sialyl lacto-N-tetrasaccharide
- Sialylation
ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
- Organic Chemistry
Cite this
Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. / Yao, Wenlong; Yan, Jun; Chen, Xi; Wang, Fengshan; Cao, Hongzhi.
In: Carbohydrate Research, Vol. 401, 12.01.2015, p. 5-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides
AU - Yao, Wenlong
AU - Yan, Jun
AU - Chen, Xi
AU - Wang, Fengshan
AU - Cao, Hongzhi
PY - 2015/1/12
Y1 - 2015/1/12
N2 - A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
AB - A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
KW - Chemoenzymatic synthesis
KW - Glycosylation
KW - Lacto-N-tetrasaccharide
KW - Sialyl lacto-N-tetrasaccharide
KW - Sialylation
UR - http://www.scopus.com/inward/record.url?scp=84910130416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84910130416&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2014.10.017
DO - 10.1016/j.carres.2014.10.017
M3 - Article
VL - 401
SP - 5
EP - 10
JO - Carbohydrate Research
JF - Carbohydrate Research
SN - 0008-6215
ER -