Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao; Jun Yan; Xi Chen; Fengshan Wang; Hongzhi Cao

doi:10.1016/j.carres.2014.10.017

Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao, Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Chemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

Original language	English (US)
Pages (from-to)	5-10
Number of pages	6
Journal	Carbohydrate Research
Volume	401
DOIs	https://doi.org/10.1016/j.carres.2014.10.017
State	Published - Jan 12 2015

Keywords

Chemoenzymatic synthesis
Glycosylation
Lacto-N-tetrasaccharide
Sialyl lacto-N-tetrasaccharide
Sialylation

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Organic Chemistry

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abstract = "A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.",

keywords = "Chemoenzymatic synthesis, Glycosylation, Lacto-N-tetrasaccharide, Sialyl lacto-N-tetrasaccharide, Sialylation",

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T1 - Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

AU - Yao, Wenlong

AU - Yan, Jun

AU - Chen, Xi

AU - Wang, Fengshan

AU - Cao, Hongzhi

PY - 2015/1/12

Y1 - 2015/1/12

N2 - A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

AB - A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

KW - Chemoenzymatic synthesis

KW - Glycosylation

KW - Lacto-N-tetrasaccharide

KW - Sialyl lacto-N-tetrasaccharide

KW - Sialylation

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