Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao, Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalCarbohydrate Research
Volume401
DOIs
StatePublished - Jan 12 2015

Fingerprint

Human Milk
Oligosaccharides
Glycosylation
Enzymes
lacto-N-neotetraose
lactosides

Keywords

  • Chemoenzymatic synthesis
  • Glycosylation
  • Lacto-N-tetrasaccharide
  • Sialyl lacto-N-tetrasaccharide
  • Sialylation

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. / Yao, Wenlong; Yan, Jun; Chen, Xi; Wang, Fengshan; Cao, Hongzhi.

In: Carbohydrate Research, Vol. 401, 12.01.2015, p. 5-10.

Research output: Contribution to journalArticle

Yao, Wenlong ; Yan, Jun ; Chen, Xi ; Wang, Fengshan ; Cao, Hongzhi. / Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. In: Carbohydrate Research. 2015 ; Vol. 401. pp. 5-10.
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