Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides

Wenlong Yao, Jun Yan, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalCarbohydrate Research
StatePublished - Jan 12 2015


  • Chemoenzymatic synthesis
  • Glycosylation
  • Lacto-N-tetrasaccharide
  • Sialyl lacto-N-tetrasaccharide
  • Sialylation

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry


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