Abstract
A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
Original language | English (US) |
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Pages (from-to) | 5-10 |
Number of pages | 6 |
Journal | Carbohydrate Research |
Volume | 401 |
DOIs | |
State | Published - Jan 12 2015 |
Keywords
- Chemoenzymatic synthesis
- Glycosylation
- Lacto-N-tetrasaccharide
- Sialyl lacto-N-tetrasaccharide
- Sialylation
ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
- Organic Chemistry