Abstract
A concise and practical chemoenzymatic synthesis of lacto-N-tetraose, a major component and one of the most common core structures of human milk oligosaccharides (HMOs) was reported. This convergent synthesis relies on the glycosylation of a readily available lactoside acceptor with a lacto-N-biose donor generated from a highly efficient one-pot two-enzyme synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-10 |
| Number of pages | 6 |
| Journal | Carbohydrate Research |
| Volume | 401 |
| DOIs | |
| State | Published - Jan 12 2015 |
Keywords
- Chemoenzymatic synthesis
- Glycosylation
- Lacto-N-tetrasaccharide
- Sialyl lacto-N-tetrasaccharide
- Sialylation
ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
- Organic Chemistry
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Cite this
Yao, W., Yan, J., Chen, X., Wang, F., & Cao, H. (2015). Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. Carbohydrate Research, 401, 5-10. https://doi.org/10.1016/j.carres.2014.10.017