Abstract
In a three-step protocol involving regioselective enzymatic acylation, per-O-trimethylsilylation, and a one-pot α-glycosidation-deprotection sequence, cholesteryl-6-O-tetradecanoyl-α-d-glucopyranoside (α-CAG) of Helicobacter pylori is afforded starting from glucose in an overall yield of 45%. The production of CAG can be scaled to make purified quantities available to the biological community for the first time.
Original language | English (US) |
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Pages (from-to) | 9083-9085 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 48 |
Issue number | 72 |
DOIs | |
State | Published - Sep 18 2012 |
ASJC Scopus subject areas
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Catalysis
- Chemistry(all)