Chemoenzymatic synthesis of 1-deaza-pyridoxal 5′-phosphate

Wait R. Griswold, Michael D. Toney

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The first synthesis of 1-deaza-pyridoxal 5′-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5′-phosphate dependent enzymes.

Original languageEnglish (US)
Pages (from-to)1352-1354
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
StatePublished - Feb 15 2010


  • Enzyme
  • Pyridoxal phosphate
  • Salicylaldehyde
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry


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