Chemoenzymatic synthesis of 1-deaza-pyridoxal 5′-phosphate

Wait R. Griswold, Michael D. Toney

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The first synthesis of 1-deaza-pyridoxal 5′-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5′-phosphate dependent enzymes.

Original languageEnglish (US)
Pages (from-to)1352-1354
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number4
DOIs
StatePublished - Feb 15 2010

Keywords

  • Enzyme
  • Pyridoxal phosphate
  • Salicylaldehyde
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Chemoenzymatic synthesis of 1-deaza-pyridoxal 5′-phosphate'. Together they form a unique fingerprint.

  • Cite this