Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans

Yan Zhang, Caicai Meng, Lan Jin, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.

Original languageEnglish (US)
Pages (from-to)11654-11657
Number of pages4
JournalChemical Communications
Issue number58
StatePublished - Jul 25 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys


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