Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites

Nicholas Strand, Abhinav Bhushan, Michael Schivo, Nicholas Kenyon, Cristina E Davis

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A wide range of metabolites are measured in the gas phase of exhaled human breath, and some of these biomarkers are frequently observed to be up- or down-regulated in certain disease states. Portable breath analysis systems have the potential for a wide range of applications in health diagnostics. However, this is currently limited by the lack of concentration mechanisms to enhance trace metabolites found in the breath to levels that can be adequately recorded using miniaturized gas-phase sensors. In this study we have created chip-based polymeric pre-concentration devices capable of absorbing and desorbing breath volatiles for subsequent chemical analysis. These devices appear to concentrate chemicals from both environmental air samples as well as directly from exhaled human breath, and these devices may have applications in lab-on-a-chip-based environmental and health monitoring systems.

Original languageEnglish (US)
Pages (from-to)516-523
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume143
Issue number2
DOIs
StatePublished - Jan 7 2010

Keywords

  • Adsorbent
  • Biomarker
  • Biosensor
  • Breath analysis
  • MEMS
  • Polypyrrole
  • Pre-concentration
  • Volatile organic compounds (VOCs)

ASJC Scopus subject areas

  • Instrumentation
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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