Abstract
Calcium-dependent inactivation (CDI) of neuronal voltage-gated Ca2+ channels (CaV1.2) is important for synaptic plasticity, which is associated with learning and memory. The Ca2+-dependent binding of calmodulin (CaM) to CaV1.2 is essential for CDI. Here we report NMR assignments for a CaM mutant (D21A/D23A/D25A/E32Q/D57A/D59A/N61A/E68Q, called CaMEF12) that contains two Ca2+ bound at the third and fourth EF-hands (EF3 and EF4) and is bound to the IQ-motif (residues 1644-1665) from CaV1.2 (BMRB accession no. 27692).
Original language | English (US) |
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Pages (from-to) | 233-237 |
Number of pages | 5 |
Journal | Biomolecular NMR assignments |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1 2019 |
Externally published | Yes |
Keywords
- Calmodulin
- CaV1.2
- CDI
- EF-hand
- IQ-motif
- Synaptic plasticity
ASJC Scopus subject areas
- Structural Biology
- Biochemistry