Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block

Hongzhi Cao, Shengshu Huang, Jiansong Cheng, Yanhong Li, Saddam Muthana, Bryan Son, Xi Chen

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues.

Original languageEnglish (US)
Pages (from-to)2863-2869
Number of pages7
JournalCarbohydrate Research
Volume343
Issue number17
DOIs
StatePublished - Nov 24 2008

Keywords

  • Chemoenzymatic synthesis
  • Oligosaccharide
  • Sialoside
  • Sialyl Lewis x

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

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