Abstract
The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues.
Original language | English (US) |
---|---|
Pages (from-to) | 2863-2869 |
Number of pages | 7 |
Journal | Carbohydrate Research |
Volume | 343 |
Issue number | 17 |
DOIs | |
State | Published - Nov 24 2008 |
Keywords
- Chemoenzymatic synthesis
- Oligosaccharide
- Sialoside
- Sialyl Lewis x
ASJC Scopus subject areas
- Biochemistry
- Analytical Chemistry
- Organic Chemistry