Abstract
Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7295-7300 |
| Number of pages | 6 |
| Journal | Journal of Organic Chemistry |
| Volume | 76 |
| Issue number | 18 |
| DOIs | |
| State | Published - Sep 16 2011 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Chemical modification of siRNA bases to probe and enhance RNA interference. / Peacock, Hayden; Kannan, Arunkumar; Beal, Peter A.; Burrows, Cynthia J.
In: Journal of Organic Chemistry, Vol. 76, No. 18, 16.09.2011, p. 7295-7300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemical modification of siRNA bases to probe and enhance RNA interference
AU - Peacock, Hayden
AU - Kannan, Arunkumar
AU - Beal, Peter A.
AU - Burrows, Cynthia J.
PY - 2011/9/16
Y1 - 2011/9/16
N2 - Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.
AB - Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.
UR - http://www.scopus.com/inward/record.url?scp=80052748882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052748882&partnerID=8YFLogxK
U2 - 10.1021/jo2012225
DO - 10.1021/jo2012225
M3 - Article
C2 - 21834582
AN - SCOPUS:80052748882
VL - 76
SP - 7295
EP - 7300
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 18
ER -