Chemical modification of siRNA bases to probe and enhance RNA interference

Hayden Peacock; Arunkumar Kannan; Peter A. Beal; Cynthia J. Burrows

doi:10.1021/jo2012225

Chemical modification of siRNA bases to probe and enhance RNA interference

Hayden Peacock, Arunkumar Kannan, Peter A. Beal, Cynthia J. Burrows

Chemistry

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.

Original language	English (US)
Pages (from-to)	7295-7300
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	76
Issue number	18
DOIs	https://doi.org/10.1021/jo2012225
State	Published - Sep 16 2011

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo2012225

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AU - Beal, Peter A.

AU - Burrows, Cynthia J.

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Chemical modification of siRNA bases to probe and enhance RNA interference

Abstract

ASJC Scopus subject areas

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