Chemical modification of siRNA bases to probe and enhance RNA interference

Hayden Peacock; Arunkumar Kannan; Peter A. Beal; Cynthia J. Burrows

doi:10.1021/jo2012225

Chemical modification of siRNA bases to probe and enhance RNA interference

Hayden Peacock, Arunkumar Kannan, Peter A. Beal, Cynthia J. Burrows

Chemistry

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.

Original language	English (US)
Pages (from-to)	7295-7300
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	76
Issue number	18
DOIs	https://doi.org/10.1021/jo2012225
State	Published - Sep 16 2011

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo2012225

Fingerprint Dive into the research topics of 'Chemical modification of siRNA bases to probe and enhance RNA interference'. Together they form a unique fingerprint.

Cite this

@article{49b5972f8a094b3f89b87310e926bef5,

title = "Chemical modification of siRNA bases to probe and enhance RNA interference",

abstract = "Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.",

author = "Hayden Peacock and Arunkumar Kannan and Beal, {Peter A.} and Burrows, {Cynthia J.}",

year = "2011",

month = sep,

day = "16",

doi = "10.1021/jo2012225",

language = "English (US)",

volume = "76",

pages = "7295--7300",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Chemical modification of siRNA bases to probe and enhance RNA interference

AU - Peacock, Hayden

AU - Kannan, Arunkumar

AU - Beal, Peter A.

AU - Burrows, Cynthia J.

PY - 2011/9/16

Y1 - 2011/9/16

N2 - Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.

AB - Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.

UR - http://www.scopus.com/inward/record.url?scp=80052748882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052748882&partnerID=8YFLogxK

U2 - 10.1021/jo2012225

DO - 10.1021/jo2012225

M3 - Article

C2 - 21834582

AN - SCOPUS:80052748882

VL - 76

SP - 7295

EP - 7300

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 18

ER -