Chemical modification of siRNA bases to probe and enhance RNA interference

Hayden Peacock, Arunkumar Kannan, Peter A. Beal, Cynthia J. Burrows

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.

Original languageEnglish (US)
Pages (from-to)7295-7300
Number of pages6
JournalJournal of Organic Chemistry
Issue number18
StatePublished - Sep 16 2011

ASJC Scopus subject areas

  • Organic Chemistry


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