Desacetylcephalothin lactone was rapidly hydrolyzed to desacetylcephalothin in 10-20% yield in phosphate and borate buffers (pH 6-9, 100°), in borate and carbonate buffers (pH 9-10.8, 25°), and in 0.01 N KOH (25°). In addition, other uncharacterized products were formed. The dosacetylcephalothin formed was isolated as its cephalothin Me ester after esterification and acetylation. These findings establish the final link in the total synthesis of cephalosporins by the lactone route.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Medicinal Chemistry|
|State||Published - 1970|
ASJC Scopus subject areas
- Organic Chemistry