Chediak-Higashi syndrome in a black infant. A light and electron microscopic study with special emphasis on erythrophagocytosis

R. Valenzuela, M. Aikawa, S. O'Regan, Sudesh P Makker

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The light and electron microscopic examination of spleen, liver and lymph nodes of a 2 mth old black infant with albinism revealed abnormal large lysosomes as well as marked erythrophagocytosis without hemosiderosis in infiltrating histiocytes and Kupffer cells. In addition, there were abnormal ocular findings. It is suggested that the erythrophagocytosis without hemosiderosis might also be a specific anatomic expression of this disease due to defective lysosomal digestion of phagocytosed erythrocytes.

Original languageEnglish (US)
Pages (from-to)483-494
Number of pages12
JournalAmerican Journal of Clinical Pathology
Volume65
Issue number4
StatePublished - 1976
Externally publishedYes

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Chediak-Higashi Syndrome
Hemosiderosis
Albinism
Electrons
Light
Histiocytes
Kupffer Cells
Lysosomes
Phagocytosis
Digestion
Spleen
Erythrocytes
Lymph Nodes
Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chediak-Higashi syndrome in a black infant. A light and electron microscopic study with special emphasis on erythrophagocytosis. / Valenzuela, R.; Aikawa, M.; O'Regan, S.; Makker, Sudesh P.

In: American Journal of Clinical Pathology, Vol. 65, No. 4, 1976, p. 483-494.

Research output: Contribution to journalArticle

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