Characterizing low fluence thresholds for in vitro photodynamic therapy

Brad A. Hartl, Henry Hirschberg, Laura Marcu, Simon R Cherry

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The translation of photodynamic therapy (PDT) to the clinic has mostly been limited to superficial diseases where traditional light delivery is noninvasive. To overcome this limitation, a variety of mechanisms have been suggested to noninvasively deliver light to deep tissues. This work explores the minimum amount of light required by these methods to produce a meaningful PDT effect in the in vitro setting under representative low fluence and wavelength conditions. This threshold was found to be around 192 mJ/cm<sup>2</sup> using the clinically approved photosensitizer aminolevulinic acid and 12 mJ/cm<sup>2</sup> for the more efficient, second generation photosensitizer TPPS<inf>2a</inf>.

Original languageEnglish (US)
Pages (from-to)770-779
Number of pages10
JournalBiomedical Optics Express
Volume6
Issue number3
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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