Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: A review of 258 dogs

C. J. McNeill, B. Overley, F. S. Shofer, Michael S Kent, C. A. Clifford, M. Samluk, S. Haney, T. J. Van Winkle, K. U. Sorenmo

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The purpose of this retrospective study was to compare Rottweilers diagnosed with osteosarcoma (OSA) with other breeds to determine whether Rottweilers experienced a more aggressive form of the disease. Two hundred and fifty-eight dogs were evaluated (102 clinical and 156 necropsy cases). In the necropsy population, Rottweilers had a younger mean age at death (7.3 versus 9 years, P = 0.006). There were no significant differences between Rottweilers and other breeds in age at diagnosis, median disease-free interval or survival time. However, Rottweilers were more likely to have metastasis to the brain (7 versus 0%, P = 0.03). These results suggest that OSA in Rottweilers may have a different biological behaviour, but this study did not confirm that these differences were associated with a worse outcome.

Original languageEnglish (US)
Pages (from-to)90-98
Number of pages9
JournalVeterinary and Comparative Oncology
Volume5
Issue number2
DOIs
StatePublished - 2007

Keywords

  • Bone tumours
  • Cancer
  • Chemotherapy
  • Dogs
  • NSAIDs
  • Sarcomas

ASJC Scopus subject areas

  • veterinary(all)

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