Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.

A. Malley, L. Werner, E. Benjamini, C. Y. Leung, Jose V Torres, N. Pangares, S. Shiigi, M. Axthelm

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of Medical Primatology
Volume20
Issue number4
StatePublished - Jun 1991
Externally publishedYes

Fingerprint

Mason-Pfizer monkey virus
B-Lymphocyte Epitopes
T-Lymphocyte Epitopes
epitopes
B-lymphocytes
T-lymphocytes
peptides
Proteins
proteins
Peptides
splenocytes
neutralizing antibodies
Neutralizing Antibodies
cell proliferation
Antibody Formation
Spleen
Cell Proliferation
viruses
antibodies
Viruses

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Malley, A., Werner, L., Benjamini, E., Leung, C. Y., Torres, J. V., Pangares, N., ... Axthelm, M. (1991). Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. Journal of Medical Primatology, 20(4), 177-181.

Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. / Malley, A.; Werner, L.; Benjamini, E.; Leung, C. Y.; Torres, Jose V; Pangares, N.; Shiigi, S.; Axthelm, M.

In: Journal of Medical Primatology, Vol. 20, No. 4, 06.1991, p. 177-181.

Research output: Contribution to journalArticle

Malley, A, Werner, L, Benjamini, E, Leung, CY, Torres, JV, Pangares, N, Shiigi, S & Axthelm, M 1991, 'Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.', Journal of Medical Primatology, vol. 20, no. 4, pp. 177-181.
Malley, A. ; Werner, L. ; Benjamini, E. ; Leung, C. Y. ; Torres, Jose V ; Pangares, N. ; Shiigi, S. ; Axthelm, M. / Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. In: Journal of Medical Primatology. 1991 ; Vol. 20, No. 4. pp. 177-181.
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