Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein.

A. Malley, L. Werner, E. Benjamini, C. Y. Leung, Jose V Torres, N. Pangares, S. Shiigi, M. Axthelm

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Abstract

Synthetic envelope peptides of a simian retrovirus (SRV-2) were used to define both T- and B-cell epitopes of the envelope protein. The SRV-2 peptide 100-106 specifically blocks rhesus anti-SRV-2 neutralizing antibody activity, and a peptide 100-106 keyhole limpet hemocyanin conjugate induces a strong antipeptide antibody response. SRV-2 peptide 100-106 and 233-249 induces good T-cell proliferation of murine spleen cells immunized with the SRV-2 virus. Thus, SRV-2 envelope peptide 100-106 represents both a T- and B-cell epitope, and peptide 233-249 a T-cell epitope.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of Medical Primatology
Volume20
Issue number4
StatePublished - Jun 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Malley, A., Werner, L., Benjamini, E., Leung, C. Y., Torres, J. V., Pangares, N., Shiigi, S., & Axthelm, M. (1991). Characterization of T- and B-cell epitopes of a simian retrovirus (SRV-2) envelope protein. Journal of Medical Primatology, 20(4), 177-181.