Characterization of rhesus macaque peripheral blood T-lymphocyte subpopulations

L. R. Ellingsworth, Bennie Osburn, L. G. Hayashi, C. A. Holmberg

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Highly enriched rhesus macaque (Macaca mulatta) peripheral blood T-lymphocytes were separated into functional subpopulations by Fc-receptors. The T-lymphocyte population was comprised of both Fc-IgM (Tμ +, 3.4 ± 1.6) and Fc-IgG (Tγ +, 16.2 ± 4.0) bearing cells. T-cells depleted of cells bearing Fc-IgG receptors (Tγ •-) and Tγ + subpopulations were characterized and assessed for functional activity. Tγ + and Tγ •- subpopulations were found to have the following characteristics: 1) Tγ + cells were stimulated by concanavalin-A (Con-A)3, pokeweed mitogen (PWM), and phytohemagglutinin-P (PHA-P), while Tγ •- cells were stimulated by Con-A and PWM, but not PHA-P; 2) Tγ {circled dash} cells were found to mediate PWM induced differentiation of autologous B-cells including EAC+ and EAC- enriched subpopulations, while Tγ + cells did not induce differentiation; 3) Tγ + cells released soluble factors which depressed mitogen stimulation of Tγ {circled dash} cells; and 4) approximately 8-10% of the Tγ + cells phagocytized IgG sensitized bovine red blood cell (BRBC) immune complexes.

Original languageEnglish (US)
Pages (from-to)517-532
Number of pages16
JournalVeterinary Immunology and Immunopathology
Volume4
Issue number5-6
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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