Characterization of Radioiodinated Ligand Binding to Amyloid β Plaques

Mei Ping Kung, Zhi Ping Zhuang, Catherine Hou, Lee-Way Jin, Hank F. Kung

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Several novel series of iodinated compounds based on the thioflavin backbone structure have been developed and characterized. These iodinated compounds showed high specific binding to amyloid β (Aβ) aggregates with subnanomolar to nanomolar affinities. Probes like IMPY and MIPA display high brain uptakes and fast washout in normal mice, resulting in low background signals (presumably no amyloid plaques present in normal mouse brain), whereas TZDM shows long brain retention in normal mice suggesting high nonspecific in vivo binding. It is likely that tracers, that is, IMPY or MIPA, with desirable in vivo properties, will provide the highest target to non-target ratio; therefore, they are most likely to be successful as imaging agents targeting Aβ plaques in the brain.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalJournal of Molecular Neuroscience
Volume20
Issue number3
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Aβ; aggregates
  • Radioiodinated ligands
  • SPECt imaging

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry
  • Genetics

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