Characterization of proteomic and metabolomic responses to dietary factors and supplements

John Astle, Jonathan T. Ferguson, J. Bruce German, George G. Harrigan, Neil L. Kelleher, Thomas Kodadek, Bryan A. Parks, Michael J. Roth, Keith W. Singletary, Craig D. Wenger, Gail B. Mahady

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Over the past decade there has been a renewed interest in research and development of both dietary and nutritional supplements. Significant advancements have been made in the scientific assessment of the quality, safety, and efficacy of these products because of the strong interest in and financial support of these projects. As research in both fields continues to advance, opportunities to use new and innovative research technologies and methodologies, such as proteomics and metabolomics, are critical for the future progress of the science. The purpose of the symposium was to begin the process of communicating new innovative proteomic and metabolomic methodologies that may be applied by researchers in both the nutrition and the natural product communities. This symposium highlighted 2 proteomic approaches, protein fingerprinting in complex mixtures with peptoid microarrays and top-down mass spectrometry for annotation of gene products. Likewise, an overview of the methodologies used in metabolomic profiling of natural products was presented, and an illustration of an integrated metabolomics approach in nutrition research was highlighted.

Original languageEnglish (US)
Pages (from-to)2787-2793
Number of pages7
JournalJournal of Nutrition
Volume137
Issue number12
StatePublished - Dec 2007

Fingerprint

Metabolomics
metabolomics
Dietary Supplements
Proteomics
proteomics
dietary supplements
Biological Products
diet
Peptoids
Research
peptide mapping
Molecular Sequence Annotation
Financial Support
nutrition research
Peptide Mapping
research and development
Complex Mixtures
funding
Mass Spectrometry
Research Design

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Astle, J., Ferguson, J. T., German, J. B., Harrigan, G. G., Kelleher, N. L., Kodadek, T., ... Mahady, G. B. (2007). Characterization of proteomic and metabolomic responses to dietary factors and supplements. Journal of Nutrition, 137(12), 2787-2793.

Characterization of proteomic and metabolomic responses to dietary factors and supplements. / Astle, John; Ferguson, Jonathan T.; German, J. Bruce; Harrigan, George G.; Kelleher, Neil L.; Kodadek, Thomas; Parks, Bryan A.; Roth, Michael J.; Singletary, Keith W.; Wenger, Craig D.; Mahady, Gail B.

In: Journal of Nutrition, Vol. 137, No. 12, 12.2007, p. 2787-2793.

Research output: Contribution to journalArticle

Astle, J, Ferguson, JT, German, JB, Harrigan, GG, Kelleher, NL, Kodadek, T, Parks, BA, Roth, MJ, Singletary, KW, Wenger, CD & Mahady, GB 2007, 'Characterization of proteomic and metabolomic responses to dietary factors and supplements', Journal of Nutrition, vol. 137, no. 12, pp. 2787-2793.
Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T et al. Characterization of proteomic and metabolomic responses to dietary factors and supplements. Journal of Nutrition. 2007 Dec;137(12):2787-2793.
Astle, John ; Ferguson, Jonathan T. ; German, J. Bruce ; Harrigan, George G. ; Kelleher, Neil L. ; Kodadek, Thomas ; Parks, Bryan A. ; Roth, Michael J. ; Singletary, Keith W. ; Wenger, Craig D. ; Mahady, Gail B. / Characterization of proteomic and metabolomic responses to dietary factors and supplements. In: Journal of Nutrition. 2007 ; Vol. 137, No. 12. pp. 2787-2793.
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