Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

N. L. Haigwood, L. Misher, S. M. Chin, M. Blair, V. Planelles, C. J. Scandella, K. S. Steimer, M. B. Gardner, Tilahun Yilma, V. M. Hirsch

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalJournal of Medical Primatology
Volume21
Issue number2-3
StatePublished - Feb 1992
Externally publishedYes

Fingerprint

Macaca
Primates
antibodies
Antibodies
Subunit Vaccines
subunit vaccines
Serum
neutralization
Vaccines
HIV
vaccines
Viruses
viruses
Proteins
proteins

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Haigwood, N. L., Misher, L., Chin, S. M., Blair, M., Planelles, V., Scandella, C. J., ... Hirsch, V. M. (1992). Characterization of group specific antibodies in primates: studies with SIV envelope in macaques. Journal of Medical Primatology, 21(2-3), 82-90.

Characterization of group specific antibodies in primates : studies with SIV envelope in macaques. / Haigwood, N. L.; Misher, L.; Chin, S. M.; Blair, M.; Planelles, V.; Scandella, C. J.; Steimer, K. S.; Gardner, M. B.; Yilma, Tilahun; Hirsch, V. M.

In: Journal of Medical Primatology, Vol. 21, No. 2-3, 02.1992, p. 82-90.

Research output: Contribution to journalArticle

Haigwood, NL, Misher, L, Chin, SM, Blair, M, Planelles, V, Scandella, CJ, Steimer, KS, Gardner, MB, Yilma, T & Hirsch, VM 1992, 'Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.', Journal of Medical Primatology, vol. 21, no. 2-3, pp. 82-90.
Haigwood NL, Misher L, Chin SM, Blair M, Planelles V, Scandella CJ et al. Characterization of group specific antibodies in primates: studies with SIV envelope in macaques. Journal of Medical Primatology. 1992 Feb;21(2-3):82-90.
Haigwood, N. L. ; Misher, L. ; Chin, S. M. ; Blair, M. ; Planelles, V. ; Scandella, C. J. ; Steimer, K. S. ; Gardner, M. B. ; Yilma, Tilahun ; Hirsch, V. M. / Characterization of group specific antibodies in primates : studies with SIV envelope in macaques. In: Journal of Medical Primatology. 1992 ; Vol. 21, No. 2-3. pp. 82-90.
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