Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.

N. L. Haigwood, L. Misher, S. M. Chin, M. Blair, V. Planelles, C. J. Scandella, K. S. Steimer, M. B. Gardner, Tilahun Yilma, V. M. Hirsch

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14 Scopus citations

Abstract

Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalJournal of Medical Primatology
Volume21
Issue number2-3
StatePublished - Feb 1992
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Haigwood, N. L., Misher, L., Chin, S. M., Blair, M., Planelles, V., Scandella, C. J., Steimer, K. S., Gardner, M. B., Yilma, T., & Hirsch, V. M. (1992). Characterization of group specific antibodies in primates: studies with SIV envelope in macaques. Journal of Medical Primatology, 21(2-3), 82-90.